Document Detail


Effects of magnesium on blood pressure and intracellular ion levels of Brazilian hypertensive patients.
MedLine Citation:
PMID:  8894790     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifteen patients with uncomplicated mild to moderate primary hypertension (7 males, 8 females, age range 36-65 years) were submitted to a double blind randomized crossover study, receiving MgO 3 times a day at a daily dose of 1.0 g (600 mg/day of magnesium) and placebo for a period of 6 weeks. This was to test the effects of oral magnesium supplementation on blood pressure and sodium, potassium, calcium and magnesium intraerythrocyte concentrations. Concomitantly, plasma renin activity and serum aldosterone was also measured. Oral magnesium reduced significantly the systolic (delta = -7.6 mmHg, P < 0.05); diastolic (delta = -3.8 mmHg, P < 0.01) and mean blood pressure (delta = -5.9 mmHg, P < 0.01). After magnesium supplementation intraerythrocyte sodium concentration was reduced (delta = -0.55 mEq/l per cell, P < 0.01) and intraerythrocyte magnesium concentration was increased (delta = 1.20 mg/dl per cell, P < 0.01). The diminution of the blood pressure correlated positively with the reduction in intraerythrocyte sodium (r = 0.66, P < 0.01) after magnesium. However, our results have shown that the blood pressure response to oral magnesium was not homogeneous. Forty percent of our patients had their blood pressure effectively controlled (more than 10 mmHg reduction in mean blood pressure), being the hypotensive effect more evident in patients with recent hypertension and in those where the reduction in intraerythrocyte sodium was significantly greater than in the non-responder individuals. Intraerythrocyte potassium and calcium, serum aldosterone, plasma renin activity and urinary sodium excretion were maintained unchanged after magnesium supplementation. These data showed that oral magnesium supplementation may reduce the blood pressure, which can be partially explained by the decrease in intracellular sodium and augment in intracellular magnesium.
Authors:
A F Sanjuliani; V G de Abreu Fagundes; E A Francischetti
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  56     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-04     Completed Date:  1997-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Affiliation:
CLINEX Clinical and Experimental Pathophysiological Center, Rio de Janeiro State University, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Aldosterone / blood
Antihypertensive Agents / administration & dosage,  pharmacokinetics,  therapeutic use*
Blood Pressure / drug effects*
Brazil
Calcium / pharmacokinetics
Cross-Over Studies
Double-Blind Method
Erythrocytes / drug effects,  metabolism
Female
Humans
Hypertension / drug therapy*
Magnesium / administration & dosage,  pharmacokinetics,  therapeutic use*
Magnesium Oxide / administration & dosage,  pharmacokinetics,  therapeutic use*
Male
Middle Aged
Placebos
Potassium / pharmacokinetics
Renin / blood
Sodium / pharmacokinetics,  urine
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Placebos; 1309-48-4/Magnesium Oxide; 52-39-1/Aldosterone; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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