Document Detail

Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-month randomized controlled weight loss trial.
MedLine Citation:
PMID:  20938438     Owner:  NLM     Status:  In-Data-Review    
Background:Regular consumption of diets with increased protein or fibre intakes may benefit body weight and composition and cardiovascular disease risk factors. Lupin flour is a novel food ingredient high in protein and fibre.Objective:To investigate the effects of a lupin-enriched diet, during and following energy restriction, on body weight and composition and cardiovascular disease risk factors in overweight individuals.Design:Participants (n=131) were recruited to a 12-month parallel-design trial. They were randomly assigned to consume lupin-enriched foods or matching high-carbohydrate control foods. All participants underwent 3 months of weight loss, 1 month of weight stabilization and 8 months of weight maintenance. Body weight and composition and cardiovascular disease risk factors were assessed at baseline, 4 and 12 months.Results:Lupin, relative to control, did not significantly influence (mean difference (95% CI)) weight loss at 4 months (0.1 kg (-1.2, 1.4)) and 12 months (-0.6 kg (-2.0, 0.8)), maintenance of weight loss from 4 to 12 months (-0.7 kg (-1.83, 0.48)) or measures of body fat and fat-free mass. Relative to control, 24-h ambulatory systolic (-1.3 mm Hg (-2.4, -0.3), P=0.016) and diastolic (-1.0 mm Hg (-1.9, -0.2), P=0.021) blood pressures were lower at 12 months but not at 4 months; fasting insulin concentrations and homeostasis model assessment (HOMA) scores were significantly lower at 4 months (-1.2 mU l(-1) (-1.3, -1.1), P=0.004 and -0.6 units (-1.0, -0.19), P=0.004) and 12 months (-1.3 mU l(-1) (-1.4, -1.1), P<0.001 and -0.7 units (-1.1, -0.24), P=0.002).Conclusions:A diet higher in protein and fibre derived from lupin-enriched foods does not enhance weight loss or improve the maintenance of weight loss. However, such a diet may provide cardiovascular health benefits in terms of insulin sensitivity and blood pressure.
R Belski; T A Mori; I B Puddey; S Sipsas; R J Woodman; T R Ackland; L J Beilin; E R Dove; N B Carlyon; V Jayaseena; J M Hodgson
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Publication Detail:
Type:  Journal Article     Date:  2010-10-12
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  35     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  810-9     Citation Subset:  IM    
1] School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia [2] The WAIMR Centre for Food and Genomic Medicine, Perth, Western Australia, Australia.
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