Document Detail

Effects of lung volume, volume history, and methacholine on lung tissue viscance.
MedLine Citation:
PMID:  2651388     Owner:  NLM     Status:  MEDLINE    
We examined the effects of lung volume change and volume history on lung resistance (RL) and its components before and during induced constriction. Eleven subjects, including three current and four former asthmatics, were studied. RL, airway resistance (Raw), and, by subtraction, tissue viscance (Vtis) were measured at different lung volumes before and after a deep inhalation and were repeated after methacholine (MCh) aerosols up to maximal levels of constriction. Vtis, which average 9% of RL at base line, was unchanged by MCh and was not changed after deep inhalation but increased directly with lung volume. MCh aerosols induced constriction by increasing Raw, which was reversed by deep inhalation in inverse proportion to responsiveness. such that the more responsive subjects reversed less after a deep breath. Responsiveness correlated directly with the degree of maximal constriction, as more responsive subjects constricted to a greater degree. These results indicate that in humans Vtis comprises a small fraction of overall RL, which is clearly volume-dependent but unchanged by MCh-induced constriction and unrelated to the degree of responsiveness of the subject.
S T Kariya; L M Thompson; E P Ingenito; R H Ingram
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  66     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  977-82     Citation Subset:  IM    
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
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MeSH Terms
Airway Resistance / drug effects
Asthma / physiopathology
Dose-Response Relationship, Drug
Lung / drug effects,  physiology*
Lung Volume Measurements
Methacholine Chloride
Methacholine Compounds / administration & dosage,  pharmacology*
Middle Aged
Grant Support
Reg. No./Substance:
0/Methacholine Compounds; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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