Document Detail

Effects of lung inflation on abdominal vascular resistance in anaesthetized dogs.
MedLine Citation:
PMID:  4080948     Owner:  NLM     Status:  MEDLINE    
In chloralose-anaesthetized dogs, the airways to each lung were separated by cuffed endobronchial cannulae and one vagus nerve was cut. We determined the effects of inflation of the innervated lung on abdominal vascular resistance, assessed in the unopened abdomen from changes in perfusion pressure at constant flow. Both static and phasic lung inflation resulted in variable responses of heart rate and abdominal vascular resistance. However, there was a significant correlation between the responses and when heart rate increased there was a significant vasoconstriction. When vasodilatation occurred this was unaffected by vascular isolation of the abdomen indicating that it could not have resulted directly from a blood-borne agent. The bradycardia and vasodilatation were prevented by administration of antagonists to histamine and prostaglandin synthesis. These experiments indicate that, when lung inflation results in tachycardia, abdominal vascular resistance increases. The responses of bradycardia and vasodilatation appear to involve the action of histamine and/or prostaglandins.
L M Wood; R Hainsworth; K H McGregor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Quarterly journal of experimental physiology (Cambridge, England)     Volume:  70     ISSN:  0144-8757     ISO Abbreviation:  Q J Exp Physiol     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-02-14     Completed Date:  1986-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206873     Medline TA:  Q J Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  575-84     Citation Subset:  IM    
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MeSH Terms
Abdomen / physiology
Heart Rate
Histamine Antagonists / pharmacology
Lung / physiology*
Prostaglandin Antagonists / pharmacology
Vascular Resistance*
Vasodilation / drug effects
Reg. No./Substance:
0/Histamine Antagonists; 0/Prostaglandin Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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