Document Detail


Effects of lowering barometric pressure on guarding behavior, heart rate and blood pressure in a rat model of neuropathic pain.
MedLine Citation:
PMID:  11166927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated whether lowering barometric pressure by 20 mmHg (LP) aggravates the guarding behavior suggestive of spontaneous pain following sciatic nerve chronic constriction injury (CCI) in rats. Systemic blood pressure (BP) and heart rate (HR) of unrestrained rats were recorded telemetrically during LP both before and after the CCI surgery. CCI rats showed guarding posture in normopressure conditions, and LP increased the cumulative time of this behavior. Baseline BP but not HR was increased following CCI. LP increased BP and HR of the rats only before the CCI surgery. Animals after CCI surgery showed variable (BP, HR) and transient (HR) responses to LP. These results indicate that (1) LP aggravated spontaneous pain and increased BP and HR in the CCI rats, and (2) CCI surgery influenced BP and HR of rats.
Authors:
J Sato; K Takanari; S Omura; K Mizumura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  299     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM    
Affiliation:
Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. jun@riem.nagoya-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Atmospheric Pressure*
Behavior, Animal / physiology*
Blood Pressure / physiology*
Disease Models, Animal
Heart Rate / physiology*
Male
Nerve Crush / adverse effects
Pain / physiopathology*
Pain Measurement
Peripheral Nervous System Diseases / physiopathology*
Rats
Rats, Sprague-Dawley
Sciatic Nerve / injuries,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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