| Effects of low temperature on contraction in papillary muscles from rabbit, rat, and hedgehog. | |
| | |
MedLine Citation:
|
PMID: 2249456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
During hibernation the body temperature may fall to only a few degrees above 0 degree C. The heart of the hedgehog continues to function whereas the hearts of nonhibernating mammals stop beating. The present study was performed to investigate and compare the mechanical responses to hypothermia in rabbits, rats, and hedgehogs. Isometric force was recorded from papillary muscles mounted in an organ bath and effects of hypothermia on the mechanical restitution curve were also compared. A reduction of bath temperature from 35 degrees C caused an increase in peak developed force. Maximum force was seen at 20 degrees C in the rabbit, 15 degrees C in the rat, and 10 degrees C in the hedgehog preparations. In all the species there was a similar prolongation of time to peak force and of time from peak to half-relaxation as temperature was lowered. An increase in resting force and after-contractions were recorded in the rabbit and rat muscles at temperatures below 15 and 10 degrees C, respectively. The rabbit and rat preparations became inexcitable at temperatures below 10 and 5 degrees C, respectively. The hedgehog papillary muscle, on the other hand, still contracted at 0 degree C and did not show increased resting force nor after-contractions. The results are consistent with the hypothesis that there is a calcium overload in cardiac cells from rabbit and rat at low temperatures but there is no calcium overload in the hedgehog muscle during hypothermia. |
| | |
Authors:
|
B Liu; B Wohlfart; B W Johansson |
Related Documents
:
|
2100316 - Is increased metabolism in rats in the cold mediated by the thyroid? 7752956 - Effects of age, reproductive status and ambient temperature on skin temperature regulat... 7182476 - Facial thermal input in the caudal trigeminal nucleus of rats reared at 30 degrees c. 15028756 - Inhibitory control at a synaptic relay. 15093886 - Role of angiotensin ii type 2 receptors and kinins in the cardioprotective effect of an... 9111766 - Analysis of the derangement of the pancreatic microcirculation in a rat caerulein pancr... |
Publication Detail:
|
Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cryobiology Volume: 27 ISSN: 0011-2240 ISO Abbreviation: Cryobiology Publication Date: 1990 Oct |
Date Detail:
|
Created Date: 1991-01-15 Completed Date: 1991-01-15 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0006252 Medline TA: Cryobiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 539-46 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, University of Lund, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Calcium / metabolism Cold Temperature* Hedgehogs Hibernation / physiology Hypothermia / physiopathology Myocardial Contraction / physiology* Papillary Muscles / physiology* Rabbits Rats Species Specificity |
| Chemical | |
Reg. No./Substance:
|
7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanism of freeze-thaw damage to liver alcohol dehydrogenase and protection by cryoprotectants and...
Next Document: Freezing of isolated thylakoid membranes in complex media. VI. The effect of pH.