| Effects of low serum triglyceride on stroke mortality: a prospective follow-up study. | |
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MedLine Citation:
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PMID: 20627296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Low serum triglyceride (TG) has been suggested as a predictor of mortality after cardiovascular disease. However, the relationship between the level of TGs and the outcome after stroke remains to be elucidated. We hypothesized that the influence of TG levels on post-stroke mortality varies according to stroke mechanism: cardioembolic (CE) vs. non-CE causes. METHODS: We prospectively enrolled a consecutive series of patients with first-ever acute ischemic stroke for 5 years (n=1067), and followed them until the end of 2007 to obtain information on mortality and cause of death. We divided the level of TG into the quartiles, and classified the patients into CE (n=226) and non-CE stroke groups (n=841). The influence of TG level on mortality (all-cause death and vascular death) was examined by univariate and multivariate analyses using Cox regression. RESULT: All-cause death and vascular death rates showed inverse relationships to the quartiles of TG levels in all patients (p<0.001, both) and also in non-CE stroke group (p<0.001, both), but not in CE stroke group (p=0.17 and p=0.37, respectively). In the Cox-regression analysis, compared with the highest quartile, the adjusted hazard ratio (HR) of the lowest quartile for all-cause death was 2.58 [95% confidence interval (CI), 1.38-4.82] and that for vascular death was 3.50 (95% CI, 1.39-8.82) in non-CE stroke group. These same associations, however, were not significant in CE stroke group. CONCLUSION: Our results indicate that low serum TG is an independent predictor of mortality after ischemic stroke brought on by non-CE causes. |
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Authors:
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Wi-Sun Ryu; Seung-Hoon Lee; Chi Kyung Kim; Beom Joon Kim; Byung-Woo Yoon |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-11 |
Journal Detail:
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Title: Atherosclerosis Volume: 212 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 299-304 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Clinical Research Center for Stroke, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biological Markers / blood Brain Ischemia / blood*, etiology, mortality* Cause of Death Chi-Square Distribution Down-Regulation Female Follow-Up Studies Humans Kaplan-Meier Estimate Male Middle Aged Prognosis Proportional Hazards Models Prospective Studies Republic of Korea / epidemiology Risk Assessment Risk Factors Stroke / blood*, etiology, mortality* Time Factors Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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