| Effects of low-power argon plasma coagulation thermoablation of Barrett's epithelium on oesophageal motility. | |
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MedLine Citation:
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PMID: 16772830 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Oesophageal dysmotility contributes to the pathogenesis of Barrett's epithelium (BE) allowing prolonged mucosal contact with injurious refluxate. Argon plasma coagulation (APC) is effective for BE ablation, but it is unknown whether the procedure affects oesophageal motility. AIM: To assess the effect of low power (30 W) APC therapy on oesophageal motility in patients with BE. METHODS: Thirty-three patients with at least 4 cm of BE underwent oesophageal manometry before and after APC ablation. All were on proton pump inhibitors. Oesophageal body peristaltic wave duration and amplitude, and lower oesophageal sphincter (LOS) pressure and length were compared before and after treatment. RESULTS: In a total of 28 men and five women, with a mean age of 63.4 years (range 39-79) and mean BE length 6.5 cm (range 4-19), macroscopic clearance was achieved in 28 patients. A small statistically significant (P<0.05) increase in peristaltic wave amplitude was seen after APC [mean (SD) mmHg before versus after: 30.4 (15.2) versus 36.2 (20.1) at 13.5 cm, 47.6 (27.1) versus 54.5 (26.8) at 8.5 cm, and 51.2 (35.3) versus 58 (34.4) at 3.5 cm above the LOS]. No changes in either peristaltic wave duration or LOS parameters [mean (SD) pressure 10.6 (5.6) versus 10.3 (4.3) mmHg; length 2.8 (1.3) versus 2.8 (1.0) cm] were observed. CONCLUSION: APC ablation of BE at a power setting of 30 W does not impair oesophageal motility. |
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Authors:
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Kumar K Basu; Vivan Talwar; John S de Caestecker |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of gastroenterology & hepatology Volume: 18 ISSN: 0954-691X ISO Abbreviation: Eur J Gastroenterol Hepatol Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-14 Completed Date: 2007-03-15 Revised Date: 2009-10-16 |
Medline Journal Info:
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Nlm Unique ID: 9000874 Medline TA: Eur J Gastroenterol Hepatol Country: England |
Other Details:
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Languages: eng Pagination: 733-7 Citation Subset: IM |
Affiliation:
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Digestive Diseases Centre, University Hospitals of Leicester NHS Trust, Leicester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antacids / therapeutic use Barrett Esophagus / drug therapy, physiopathology, surgery* Combined Modality Therapy Esophageal Sphincter, Lower / physiopathology Esophagus / physiopathology* Female Humans Hydrogen-Ion Concentration Laser Coagulation* Male Manometry / methods Middle Aged Peristalsis Postoperative Period Proton Pumps / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 0/Proton Pumps |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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