| Effects of low potassium dextran glucose solution on oleic acid-induced acute lung injury in juvenile piglets. | |
| | |
MedLine Citation:
|
PMID: 21933626 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Epithelial dysfunction in lungs plays a key role in the pathogenesis of acute lung injury. The beneficial effects of low potassium dextran glucose solution (LPD) have been reported in lung preservation, and LPD enables injured alveolar pneumocytes to recover. So we hypothesized that systemic administration of LPD may have benefits in treating acute lung injury. We investigated the effects of LPD on arterial blood gas and levels of some cytokines in oleic acid-induced acute lung injury in juvenile piglets. METHODS: Oleic acid (0.1 ml/kg) was intrapulmonarily administered to healthy anesthetized juvenile piglets. Ten animals were randomly assigned to two groups (n = 5 each): oleic acid-induced group (control group) with intravenous infusion of 12.5 ml/kg of lactated Ringer's solution 30 minutes before administration of oleic acid and LPD group with systemic administration of LPD (12.5 ml/kg) 30 minutes before injecting oleic acid. Blood gas variables and concentrations of tumor necrosis factor alpha, endothelin 1 and interleukin 10 were measured before and every 1 hour for 6 hours after initial lung injury. RESULTS: Compared with control group, blood pH, partial pressure of arterial oxygen to fraction of inspired oxygen ratio, partial pressure of arterial carbon dioxide, and mean pulmonary arterial pressure in LPD group were improved (P < 0.05 or 0.01). Six hours after lung injury, concentration of tumor necrosis factor alpha in lung tissue was lower in LPD group than control group (P < 0.05). Plasmic concentration of endothelin 1 showed lower in LPD group while plasmic concentration of interleukin 10 showed higher in LPD group (P < 0.05). CONCLUSIONS: Before lung injury, systemic administration of LPD can improve gas exchange, attenuate pulmonary hypertension, decrease plasmic levels of endothelin 1, increase interleukin 10 and decrease concentration of tumor necrosis factor alpha in lung tissue in oleic acid-induced acute lung injury in juvenile piglets. |
| | |
Authors:
|
Feng Ling; Ying-Long Liu; Ai-Jun Liu; Dong Wang; Qiang Wang |
Related Documents
:
|
12626336 - Pulmonary vascular dysfunction in preterm lambs with chronic lung disease. 8233736 - Surfactant therapy and intracranial hemorrhage: review of the literature and results of... 6833326 - The role of lavage in preventing hemodynamic and blood-gas changes during cemented arth... 1828856 - Reactive hyperemia in term neonates and adults--a laser doppler fluxmetry study of skin... 7584926 - Endocrine and auto-paracrine factors in the pathogenesis of primary hypertension. 8428786 - Mild hypovolemic stress alters autonomic modulation of heart rate. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Chinese medical journal Volume: 124 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-09-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
|
Languages: eng Pagination: 2196-202 Citation Subset: IM |
Affiliation:
|
Department of Pediatric Cardiac Surgery Center, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protective role of mitochondrial K-ATP channel and mitochondrial membrane transport pore in rat kidn...
Next Document: Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis.