| Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on Brain Structure and Function: A study at 4T. | |
| | |
MedLine Citation:
|
PMID: 21741405 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: More than 100,000 US troops were potentially exposed to chemical warfare agents sarin (GB) and cyclosarin (GF) when an ammunition dump at Khamisiyah, Iraq was destroyed during the 1991 Persian Gulf War (GW). We previously found reduced total gray matter (GM) volume in 40 GW veterans with suspected GB/GF exposure relative to 40 matched, unexposed GW veterans on a 1.5T MR scanner. In this study, we reexamine the relationship between GB/GF exposure and volumetric measurements of gross neuroanatomical structures in a different cohort of GW veterans on a 4T MR scanner. METHODS: Neuropsychological and magnetic resonance imaging (MRI) data from a cross sectional study on Gulf War Illness performed between 2005 and 2010 were used in this study. 4T MRI data were analyzed using automated image processing techniques that produced volumetric measurements of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF). RESULTS: Binary comparisons of 64 GB/GF exposed veterans and 64 'matched', unexposed veterans revealed reduced GM (p=0.03) and WM (p=0.03) volumes in the exposed veterans. Behaviorally, exposed veterans committed more errors of omission (p=0.02) and tended to have slower responses (p=0.05) than unexposed veterans on the Continuous Performance Test (CPT), a measure sustained and selective attention. Regression analyses confirmed that GB/GF exposure status predicted GM (β=-0.11, p=0.02) and WM (β=-0.14, p=0.03) volumes, and number of CPT omission errors (β=0.22, p=0.02) over and above potentially confounding demographic, clinical, and psychosocial variables. There was no dose-response relationship between estimated levels of GB/GF exposure and brain volume. However, we did find an effect of Gulf War Illness/Chronic Mulitsymptom Illness on both GM and WM volume in the GB/GF exposed veterans. CONCLUSIONS: These findings confirm previous reports by our group and others of central nervous system pathology in GW veterans with suspected exposure to low levels of GB/GF two decades after the exposure. |
| | |
Authors:
|
Linda L Chao; Linda Abadjian; Jennifer Hlavin; Deiter J Meyerhoff; Michael W Weiner |
Related Documents
:
|
21059375 - Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery ... 1562885 - Gadopentetate dimeglumine in craniospinal magnetic resonance imaging: common uses and s... 20821085 - Effects of inversion and saturation times on relationships between contrast agent conce... 12202725 - Drug-induced pneumonitis: thin-section ct findings in 60 patients. 15517205 - Scanning electrochemical microscopy (secm) of nanolitre droplets using an integrated wo... 10459465 - Neurogenic bladder dysfunction. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-29 |
Journal Detail:
|
Title: Neurotoxicology Volume: - ISSN: 1872-9711 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-7-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Center for Imaging of Neurodegenerative Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, CA, United States; Department of Psychiatry, University of California, San Francisco, CA, United States; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, United States. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of myocyte enhancer factor-2 transcription factors by neurotoxins.
Next Document: Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at...