| Effects of a low-glycemic load diet in overweight and obese pregnant women: a pilot randomized controlled trial. | |
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MedLine Citation:
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PMID: 20962162 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The optimal diet for pregnancy that is complicated by excessive weight is unknown. OBJECTIVE: We aimed to examine the effects of a low-glycemic load (low-GL) diet in overweight and obese pregnant women. DESIGN: We randomly assigned 46 overweight or obese pregnant women to receive a low-GL or a low-fat diet. Participants received carbohydrate-rich foods, fats, and snack foods through home delivery or study visits. The primary outcome was birth weight z score. Other endpoints included infant anthropometric measurements, gestational duration, maternal weight gain, and maternal metabolic parameters. RESULTS: There were no significant differences in birth weight z score or other measures of infant adiposity between groups. However, in the low-GL compared with the low-fat group, gestational duration was longer (mean ± SD: 39.3 ± 1.1 compared with 37.9 ± 3.1 wk; P = 0.05) and fewer deliveries occurred at ≤ 38.0 wk (13% compared with 48%, P = 0.02; with exclusion of planned cesarean deliveries: 5% compared with 53%; P = 0.002). Adjusted head circumference was greater in the low-GL group (35.0 ± 0.8 compared with 34.2 ± 1.3 cm, P = 0.01). Women in the low-GL group had smaller increases in triglycerides [median (interquartile range): 49 (19, 70) compared with 93 (34, 129) mg/dL; P = 0.03] and total cholesterol [13 (0, 36) compared with 33 (22, 56) mg/dL, P = 0.04] and a greater decrease in C-reactive protein [-2.5 (-5.5, -0.7) compared with -0.4 (-1.4, 1.5) mg/dL, P = 0.007]. CONCLUSIONS: A low-GL diet resulted in longer pregnancy duration, greater infant head circumference, and improved maternal cardiovascular risk factors. Large-scale studies are warranted to evaluate whether dietary intervention during pregnancy aimed at lowering GL may be useful in the prevention of prematurity and other adverse maternal and infant outcomes. This trial is registered at clinicaltrials.gov as NCT00364403. |
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Authors:
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Erinn T Rhodes; Dorota B Pawlak; Tamara C Takoudes; Cara B Ebbeling; Henry A Feldman; Margaret M Lovesky; Emily A Cooke; Michael M Leidig; David S Ludwig |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-23 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1306-15 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology, Children's Hospital Boston, Boston, MA, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00364403 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight C-Reactive Protein / metabolism* Cholesterol / blood Female Gestational Age Glycemic Index* Head / anatomy & histology* Humans Infant, Newborn Lipids / blood* Obesity / blood, diet therapy* Overweight / blood, diet therapy Pilot Projects Pregnancy Pregnancy Complications / blood, diet therapy* Single-Blind Method Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR01032/RR/NCRR NIH HHS; P30 DK040561-15/DK/NIDDK NIH HHS; R03DK073335/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Triglycerides; 57-88-5/Cholesterol; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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