Document Detail

Effects of low dose methylmercury administration during the postnatal brain growth spurt in rats.
MedLine Citation:
PMID:  17141469     Owner:  NLM     Status:  MEDLINE    
Male Sprague-Dawley rats from eight litters were orally administered 0.75 mg/kg/day methylmercury (MeHg) chloride from postnatal day (PD) 14 to PD 23. One male pup per litter from eight different litters per treatment group was used. Each pup was used only for a single behavioral test and tested once. The MeHg dose level resulted in Hg brain concentrations of 0.82+/-0.05 microg/g tissue (n=4). Locomotor behavior was studied in the Opto-Varimex apparatus by testing rats (n=8) weekly from PD 24 to PD 45. Performance of rats (n=8) on learning paradigm was analysed on PD 90. MeHg treatment induced a significant reduction in the number of rearings without altering the distance travelled, the resting time and the time spent in the central part of the arena. Results of conditioned avoidance task showed that, unlike control rats, MeHg-treated animals did not show improvement over blocks and never reached a level of performance that would indicate significant learning had taken place. The present results show that low level exposure to MeHg during late brain growth spurt induces subtle and persistent motor and learning deficits, further underlining the serious potential hazard for the exposed children.
Addolorata Coluccia; Pietro Borracci; Arcangela Giustino; Mineshi Sakamoto; Maria Rosaria Carratù
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-25
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  29     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2007 Mar-Apr
Date Detail:
Created Date:  2007-03-19     Completed Date:  2007-06-01     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  282-7     Citation Subset:  IM    
Department of Pharmacology and Human Physiology, Medical School, University of Bari, Policlinico, Piazza G. Cesare 11, 70124 Bari, Italy.
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MeSH Terms
Administration, Oral
Age Factors
Analysis of Variance
Animals, Newborn
Avoidance Learning / drug effects
Behavior, Animal / drug effects*
Body Weight / drug effects
Brain / drug effects*,  growth & development,  pathology
Methylmercury Compounds / metabolism,  toxicity*
Motor Activity / drug effects
Organ Size / drug effects
Psychomotor Performance / drug effects
Reaction Time / drug effects
Reg. No./Substance:
0/Methylmercury Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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