| Effects of low-dose dobutamine on left ventricular diastolic filling in children. | |
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MedLine Citation:
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PMID: 8662043 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the effects of dobutamine on the Doppler transmitral flow pattern in children with normal left ventricular function, Doppler echocardiography was used to measure the transmitral flow in 14 healthy children before and during infusion of dobutamine (5 micrograms/kg per minute). Cardiac output was measured by the thermodilution method, and stroke volume was calculated as the cardiac output divided by the heart rate. Dobutamine increased the peak velocity and flow velocity-time integral of early diastolic filling without changing those of atrial contraction and normalized peak velocity of early diastolic filling, suggesting an increase in left ventricular relaxation. Dobutamine increased the stroke volume and rate-corrected mean velocity of fiber shortening with reduced end-systolic wall stress, indicating an increase in left ventricular contractility. The percentage of increase in the flow velocity-time integral of early diastolic filling during dobutamine infusion tended to correlate with the increase in stroke volume (r = 0.67, p < 0.05) and with the decrease in end-systolic wall stress (r = -0.61, p < 0.05). Our results suggest that low-dose dobutamine increases left ventricular relaxation with enhanced systolic function. The observed decreased endsystolic wall stress might have caused enhanced relaxation characteristics with dobutamine. |
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Authors:
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K Harada; M Tamura; T Ito; T Suzuki; G Takada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric cardiology Volume: 17 ISSN: 0172-0643 ISO Abbreviation: Pediatr Cardiol Publication Date: 1996 Jul-Aug |
Date Detail:
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Created Date: 1997-02-07 Completed Date: 1997-02-07 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 220-5 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Akita University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Output Cardiotonic Agents / pharmacology* Child Child, Preschool Diastole / drug effects Dobutamine / pharmacology* Echocardiography, Doppler Hemodynamics / drug effects Humans Infant Stroke Volume Ventricular Function, Left / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Cardiotonic Agents; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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