Document Detail


Effects of low-dose dobutamine on left ventricular function in normal subjects as assessed by gated single-photon emission tomography myocardial perfusion studies.
MedLine Citation:
PMID:  10541828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrocardiography gated single-photon emission tomography (gated SPET) allows the assessment of regional perfusion and function simultaneously and in full spatial congruency. In this study changes in global and regional left ventricular function in response to dobutamine infusion were assessed in ten healthy volunteers using sequential gated SPET myocardial perfusion acquisitions. Four consecutive gated SPET images were recorded 60 min after injection of 925 MBq technetium-99m tetrofosmin on a three-head camera equipped with focussing collimators. Two acquisitions were made at rest (baseline 1 and 2), and the third and fourth acquisitions were started 5 min after the beginning of the infusion of 5 and 10 microg kg(-1) min(-1) dobutamine, respectively. Systolic wall thickening (WT) was quantified using a method based on circumferential profile analysis. Left ventricular ejection fraction (LVEF) and volumes were calculated automatically using the Cedars-Sinai program. Nine of the ten subjects presented a definite increase in WT during dobutamine infusion. WT increased on average from 46%+/-14% at baseline to 71%+/-23% (range: 37%-106%; P<0.05) during 5 microg kg(-1) min(-1) dobutamine infusion and to 85%+/-25% (range: 62%-123%; P<0.05 with respect to WT at 5 microg kg(-1) min(-1)) during 10 microg kg(-1) min(-1) dobutamine infusion. Apical segments showed the largest WT at baseline. The average WT response to dobutamine was similar for all parts of the myocardium. It is concluded that changes in WT induced by infusion of low-dose dobutamine can be assessed by sequential gated SPET myocardial perfusion studies. The "stress gated SPET" protocol proposed in this study might be helpful to distinguish viable from scar tissue in patients with coronary artery disease, by demonstrating a preserved inotropic response in hypoperfused myocardium.
Authors:
H Everaert; C Vanhove; P R Franken
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  26     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-02-17     Completed Date:  2000-02-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1298-303     Citation Subset:  IM    
Affiliation:
Divison of Nuclear Medicine, University Hospital, Free University of Brussels (AZ VUB), Laarbeeklaan 101, B-1090 Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology*
Adult
Coronary Circulation / drug effects*
Dobutamine / pharmacology*
Electrocardiography / drug effects
Heart / radionuclide imaging*
Heart Ventricles / radionuclide imaging
Hemodynamics / drug effects
Humans
Male
Models, Anatomic
Perfusion
Stroke Volume / drug effects
Tomography, Emission-Computed, Single-Photon
Ventricular Function, Left / drug effects*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 34368-04-2/Dobutamine

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