Document Detail


Effects of low-dose aspirin on endothelial function in hypertensive patients.
MedLine Citation:
PMID:  11714127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It has been reported that administration of low-dose aspirin significantly reduces the frequency of major cardiovascular events in patients with hypertension and coronary artery disease. It is generally considered that the preventative effects of long-term aspirin administration on major cardiovascular events are due to the inhibition of platelet aggregation. HYPOTHESIS: It is not known whether administration of low-dose aspirin restores endothelium-dependent vasodilatation, and this study was undertaken to prove or disprove this question in patients with hypertension. METHODS: Flow-mediated endothelium-dependent dilatation and glyceryl trinitrate-induced endothelium-independent dilatation were investigated in 18 hypertensive patients and 10 normotensive control subjects. In the hypertensive patients, flow-mediated dilatation was investigated and cyclic guanosine monophosphate plasma (cGMP) was measured before and at 8 weeks after the administration of 162 mg of aspirin. RESULTS: Flow-mediated dilatation before aspirin administration was more reduced in the hypertensive patients than in the control subjects (6.4+/-2.0% vs. 11.3+/-2.3%, p <0.0001). Glyceryl trinitrate-induced dilatation before aspirin administration was similar in hypertensive patients and control subjects. Flow-mediated dilatation after aspirin administration was improved compared with that before aspirin administration (10.4+/-3.5% vs. 6.4+/-2.0%, p<0.0004). The cGMP product after aspirin administration was significantly higher than that before aspirin administration. CONCLUSIONS: Administration of low-dose aspirin may restore the endothelium-dependent vasodilatation in hypertensive patients. Furthermore, increased nitric oxide production may play a partial role in the improvement in endothelial function induced by administration of low-dose aspirin.
Authors:
H Monobe; H Yamanari; K Nakamura; T Ohe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  24     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-20     Completed Date:  2002-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  705-9     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Okayama University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aspirin / administration & dosage,  pharmacology*
Blood Volume / drug effects,  physiology
Case-Control Studies
Cyclic GMP / blood
Endothelium, Vascular / drug effects*,  physiology
Female
Humans
Hypertension / drug therapy*,  physiopathology
Male
Middle Aged
Regional Blood Flow / drug effects,  physiology
Vasodilation / physiology*
Vasodilator Agents / administration & dosage,  pharmacology*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 50-78-2/Aspirin; 7665-99-8/Cyclic GMP

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