Document Detail


Effects of low-dose aspirin on clinic and ambulatory blood pressure in treated hypertensive patients. Collaborative Group of the Primary Prevention Project (PPP)--Hypertension study.
MedLine Citation:
PMID:  10912743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonsteroidal antiinflammatory drugs may affect blood pressure (BP) control in hypertensive patients receiving drug treatment, but data on the effects of low-dose aspirin are scanty. This study assessed the effects of chronic treatment with low doses of aspirin (100 mg/day) on clinic and ambulatory systolic (SBP) and diastolic (DBP) BP in hypertensives on chronic, stable antihypertensive therapy. The study was conducted in the framework of the Primary Prevention Project (PPP), a randomized, controlled factorial trial on the preventive effect of aspirin or vitamin E in people with one or more cardiovascular risk factors. Fifteen Italian hypertension units studied 142 hypertensive patients (76 men, 66 women; mean age 59 +/- 5.9 years) treated with different antihypertensive drugs: 71 patients were randomized to aspirin and 71 served as controls. All patients underwent a clinic BP evaluation with an automatic sphygmomanometer and a 24-h ambulatory BP monitoring, at baseline and after 3 months of aspirin treatment. At the end of the study the changes in clinic SBP and DBP were not statistically different in treated and untreated subjects. Ambulatory SBP and DBP after 3 months of aspirin treatment were similar to baseline: deltaSBP -0.5 mmHg (95% confidence intervals [CI] from -1.9 to +2.9 mm Hg) and deltaDBP -1.1 mm Hg (95% CI from -2.5 to +0.3 mm Hg). The pattern was similar in the control group. No interaction was found between aspirin and the most used antihypertensive drug classes (angiotensin converting enzyme inhibitors and calcium antagonists). Despite the relatively small sample size our results seem to exclude any significant influence of low-dose aspirin on BP control in hypertensives under treatment.
Authors:
F Avanzini; G Palumbo; C Alli; M C Roncaglioni; E Ronchi; M Cristofari; A Capra; S Rossi; L Nosotti; C Costantini; R Pietrofeso
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  13     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-02     Completed Date:  2000-11-21     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  611-6     Citation Subset:  IM    
Affiliation:
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. avanzini@irfmn.mnegri.it
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Aspirin / administration & dosage*
Blood Pressure / drug effects*,  physiology
Blood Pressure Monitoring, Ambulatory*
Circadian Rhythm / physiology
Drug Therapy, Combination
Female
Humans
Hypertension / physiopathology,  prevention & control*
Male
Middle Aged
Risk Factors
Vitamin E / administration & dosage
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 1406-18-4/Vitamin E; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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