Document Detail

Effects of low-density lipoprotein apheresis on coronary and carotid atherosclerosis and diabetic scleredema in patients with severe hypercholesterolemia.
MedLine Citation:
PMID:  11724508     Owner:  NLM     Status:  MEDLINE    
Correlations between serum cholesterol levels and progression of coronary and peripheral atherosclerosis have been found in many recent studies. It has also been demonstrated that aggressive cholesterol-lowering therapy with low-density lipoprotein (LDL) apheresis, a method of LDL elimination by extracorporeal circulation, is effective not only for coronary artery disease, but also for systemic circulatory disturbance in severe hypercholesterolemic patients with familial hypercholesterolemia (FH) in particular. We found that LDL apheresis treatment with medical therapy improved coronary atherosclerotic lesions, based on coronary angiography evaluation and histopathological observation, suppressed progression of early carotid atherosclerotic lesions on annual B-mode ultrasonography, and improved diabetic scleredema in FH patients. This effectiveness of LDL apheresis appears to be due to recovery of vascular endothelial function and improvement of blood rheology. For diseases that are possibly due to circulation disturbance and that are intractable with drugs alone. LDL apheresis may be worth trying, particularly for patients complicated by hyperlipemia.
N Koga
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis     Volume:  5     ISSN:  1091-6660     ISO Abbreviation:  Ther Apher     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-11-28     Completed Date:  2002-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9706703     Medline TA:  Ther Apher     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-51     Citation Subset:  IM    
Department of Cardiology, Shin-Koga Hospital, Kurume, Japan.
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MeSH Terms
Anticholesteremic Agents / therapeutic use
Carotid Artery Diseases / prevention & control*
Coronary Angiography
Coronary Artery Disease / prevention & control*
Disease Progression
Hypercholesterolemia / complications,  therapy*
Lipoproteins, LDL / blood,  isolation & purification*
Skin Diseases / prevention & control*
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Lipoproteins, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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