Document Detail

Effects of low concentrations of enflurane on probability learning.
MedLine Citation:
PMID:  747689     Owner:  NLM     Status:  MEDLINE    
The effects of controlled subanaesthetic concentrations of enflurane on learning behaviour and on ability to change previously developed decision strategies were studied in 10 male volunteers, using a probability learning task. Subjects were instructed to predict on each of 200 consecutive trials, whether a left or a right light would appear. The appearance of lights was pre-determined by a set relative frequency unknown to the subject. The relative frequency was automatically changed at the end of the first 100 trials, from 8/10 lights in the left side to 4/10. It was found that enflurane at subanaesthetic concentration of 0.25% (end-tidal) slowed the rate of learning, and increased the number of trials required for readjusting the prediction strategy to the changed situation.
S Bentin; G I Collins; N Adam
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  50     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-06-26     Completed Date:  1979-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1179-83     Citation Subset:  IM    
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MeSH Terms
Enflurane / administration & dosage,  pharmacology*
Methyl Ethers / pharmacology*
Probability Learning / drug effects*
Thinking / drug effects
Visual Perception / drug effects
Reg. No./Substance:
0/Methyl Ethers; 13838-16-9/Enflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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