Document Detail


Effects of lovastatin on biliary lipid secretion and bile acid metabolism in humans.
MedLine Citation:
PMID:  2010695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lovastatin, an inhibitor of HMG-CoA reductase, lowers cholesterol saturation of bile. To determine the mechanism of this effect and further define the role of cholesterol synthesis in regulation of biliary lipid metabolism, we studied ten human volunteers in a control period and again after 5-6 weeks on lovastatin, 40 mg b.i.d. Mean sterol production from acetate in mononuclear leukocytes fell from 1.18 to 0.84 pmol/min per 10(6) cells on lovastatin (P less than 0.02). Concomitantly there was reduction in mean biliary secretion of cholesterol from 143 to 96 mumol/h (P less than 0.02). On lovastatin, mean pool size of bile acids by the Lindstedt method fell from 3193 to 2917 mumol (one-sided P = 0.05) and mean pool size by the one-sample method fell from 5158 to 4091 mumol (P less than 0.002). Lovastatin had no effect on mean fractional turnover rate of either cholic acid (0.77 vs. 0.74 day-1) or chenodeoxycholic acid (0.51 vs. 0.54 day-1). Mean total bile acid synthesis was lower on lovastatin (1443 vs. 1240 mumol/day), but the difference did not quite achieve statistical significance. In humans, inhibition of cholesterol synthesis by lovastatin lowers biliary cholesterol saturation by reducing cholesterol secretion into bile. Bile acid pool size, and perhaps bile acid synthesis, are also reduced by this inhibition.
Authors:
J C Mitchell; G M Logan; B G Stone; W C Duane
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of lipid research     Volume:  32     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-05-09     Completed Date:  1991-05-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Veterans Administration Medical Center, Minneapolis, MN.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bile Acids and Salts / blood*
Biliary Tract / drug effects,  secretion*
Chenodeoxycholic Acid / blood
Cholesterol / biosynthesis
Cholic Acid
Cholic Acids / blood
Humans
Lipids / secretion*
Lovastatin / pharmacology*
Male
Middle Aged
Sitosterols / blood
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholic Acids; 0/Lipids; 0/Sitosterols; 474-25-9/Chenodeoxycholic Acid; 57-88-5/Cholesterol; 5779-62-4/sitosterol; 75330-75-5/Lovastatin; 81-25-4/Cholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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