Document Detail

Effects of lorazepam and diazepam on conscious and automatic memory processes.
MedLine Citation:
PMID:  8880945     Owner:  NLM     Status:  MEDLINE    
Recent studies exploring benzodiazepine memory effects have used the distinction between explicit and implicit tasks. There is now increasing evidence that implicit tasks can be "contaminated" by conscious uses of memory and that unconscious (automatic) use of memory can contaminate explicit tasks, leading to mistaken estimates of their respective influences on memory performance. The aim of the present double-blind, double-placebo study was to assess the memory effects of diazepam and lorazepam using a process-dissociation procedure in a stem-completion task, this procedure providing uncontaminated estimates of conscious and automatic memory processes. The memory task was administrated to 60 healthy volunteers randomly assigned to one of three parallel groups (placebo, diazepam 0.3 mg/kg, lorazepam 0.038 mg/kg). Lorazepam markedly reduced conscious as well as automatic influences of memory. Diazepam also reduced conscious uses of memory, albeit to a lesser extent than lorazepam, but did not decrease the influence of automatic memory. Secondary analyses showed that when the deleterious effect on conscious uses of memory was equated between a diazepam subgroup and the lorazepam group, only lorazepam impaired the automatic use of memory. This study strongly suggests a qualitative difference in the memory effects of the two benzodiazepines. It has some implications regarding the relationships between states of consciousness and memory processes.
P Vidailhet; M Kazès; J M Danion; F Kauffmann-Muller; D Grangé
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Psychopharmacology     Volume:  127     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-10     Completed Date:  1997-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
INSERM Unité 405, Département de Psychiatrie, Hôpitaux Universitaires de Strasbourg, France.
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MeSH Terms
Anti-Anxiety Agents / pharmacology*
Cognition / drug effects
Consciousness / drug effects
Diazepam / pharmacology*
Lorazepam / pharmacology*
Memory / drug effects*
Mental Recall / drug effects
Reg. No./Substance:
0/Anti-Anxiety Agents; 439-14-5/Diazepam; 846-49-1/Lorazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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