Document Detail


Effects of lorazepam and diazepam on conscious and automatic memory processes.
MedLine Citation:
PMID:  8880945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies exploring benzodiazepine memory effects have used the distinction between explicit and implicit tasks. There is now increasing evidence that implicit tasks can be "contaminated" by conscious uses of memory and that unconscious (automatic) use of memory can contaminate explicit tasks, leading to mistaken estimates of their respective influences on memory performance. The aim of the present double-blind, double-placebo study was to assess the memory effects of diazepam and lorazepam using a process-dissociation procedure in a stem-completion task, this procedure providing uncontaminated estimates of conscious and automatic memory processes. The memory task was administrated to 60 healthy volunteers randomly assigned to one of three parallel groups (placebo, diazepam 0.3 mg/kg, lorazepam 0.038 mg/kg). Lorazepam markedly reduced conscious as well as automatic influences of memory. Diazepam also reduced conscious uses of memory, albeit to a lesser extent than lorazepam, but did not decrease the influence of automatic memory. Secondary analyses showed that when the deleterious effect on conscious uses of memory was equated between a diazepam subgroup and the lorazepam group, only lorazepam impaired the automatic use of memory. This study strongly suggests a qualitative difference in the memory effects of the two benzodiazepines. It has some implications regarding the relationships between states of consciousness and memory processes.
Authors:
P Vidailhet; M Kazès; J M Danion; F Kauffmann-Muller; D Grangé
Related Documents :
8987015 - Memory systems and the psychoanalytic retrieval of memories of trauma.
21048965 - No childhood advantage in the acquisition of skill in using an artificial language rule.
18052785 - Error and deviance processing in implicit and explicit sequence learning.
20721805 - Recollective performance advantages for implicit memory tasks.
1319705 - Chlordiazepoxide-induced working memory impairments: site specificity and reversal by f...
17445245 - Lesions of rat infralimbic cortex enhance renewal of extinguished appetitive pavlovian ...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Psychopharmacology     Volume:  127     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-10     Completed Date:  1997-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  63-72     Citation Subset:  IM    
Affiliation:
INSERM Unité 405, Département de Psychiatrie, Hôpitaux Universitaires de Strasbourg, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Anxiety Agents / pharmacology*
Cognition / drug effects
Consciousness / drug effects
Diazepam / pharmacology*
Female
Humans
Lorazepam / pharmacology*
Male
Memory / drug effects*
Mental Recall / drug effects
Chemical
Reg. No./Substance:
0/Anti-Anxiety Agents; 439-14-5/Diazepam; 846-49-1/Lorazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Assessing the sensory role of nicotine in cigarette smoking.
Next Document:  The effects of paroxetine given repeatedly on the 5-HT receptor subpopulations in the rat brain.