| Effects of long-term treatment with trandolapril on augmented vasoconstriction in rats with chronic heart failure. | |
| | |
MedLine Citation:
|
PMID: 8989645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Despite the clinical relevance of angiotensin I-converting enzyme (ACE) inhibitors, their effects on impaired vascular function in patients and animals with chronic heart failure (CHF) have not been fully understood. This study was undertaken to determine whether long-term treatment with an ACE inhibitor improved the altered contractile properties of vessels from rats with CHF. METHODS AND RESULTS: Twelve weeks after coronary artery ligation, the rats were sacrificed and the isometric tension development of thoracic aorta, pulmonary artery, and mesenteric artery with and without endothelium was examined. Contractile responses to norepinephrine and prostaglandin F2 alpha were augmented in endothelium-intact, but not in endothelium-denuded, thoracic aorta and pulmonary artery segments of the rat with CHF. The contractile response to angiotensin II was augmented in endothelium-denuded mesenteric artery segments of the rat with CHF, which was attenuated by indomethacin or diclofenac sodium but not by bunazosin. Trandolapril (3 mg/kg/d) was administered orally from the 2nd to 12th week after the operation. Treatment with trandolapril reversed the augmented contractile response of the rat with CHF to norepinephrine, prostaglandin F2 alpha, and angiotensin II almost to the levels in the sham-operated rat. CONCLUSIONS: The results demonstrate that an ACE inhibitor is capable of reversing altered vascular function in the rat with CHF, suggesting that vascular beds are possible sites of action for ACE inhibitors in the therapy for CHF. |
| | |
Authors:
|
Y Okumura; Y Nasa; A Sanbe; W Toga; S Takeo |
Related Documents
:
|
1978775 - Role of elastase and lysyl oxidase activity in spontaneous rupture of internal elastic ... 2864255 - Animal model for the study of internal anal sphincter activity. 10461855 - Effect of bupranolol for brl37344 and noradrenaline-induced relaxations mediating atypi... 12738085 - Antispasmodic effect of three fractions of hydroalcoholic extract of pycnocycla spinosa. 2624825 - Metabolism of collagen in bone of adjuvant induced arthritic rat. 6188995 - Bombesin-like immunoreactivity in sympathetic ganglia. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cardiac failure Volume: 2 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 1996 Dec |
Date Detail:
|
Created Date: 1997-03-25 Completed Date: 1997-03-25 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 301-10 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Tokyo University of Pharmacy and Life Science, Hachioji, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Angiotensin II / administration & dosage, pharmacology* Angiotensin-Converting Enzyme Inhibitors / administration & dosage, therapeutic use* Animals Coronary Vessels / drug effects Culture Techniques Disease Models, Animal Drug Interactions Heart Failure / drug therapy* Hemodynamics / drug effects Indoles / administration & dosage, therapeutic use* Male Muscle, Smooth, Vascular / drug effects*, physiopathology Norepinephrine / administration & dosage, pharmacology* Prostaglandins F / administration & dosage, pharmacology* Rats Rats, Wistar Reference Values Vasoconstriction / drug effects Vasoconstrictor Agents / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Indoles; 0/Prostaglandins F; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 51-41-2/Norepinephrine; 87679-37-6/trandolapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term 1-carnitine treatment prolongs the survival in rats with adriamycin-induced heart failure.
Next Document: Direct effects of chronic beta-adrenergic receptor blockade on left ventricular and myocyte function...