| Effects of long-term treatment with carvedilol on myocardial blood flow in idiopathic dilated cardiomyopathy. | |
| | |
MedLine Citation:
|
PMID: 17237134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess whether chronic treatment with carvedilol can increase myocardial blood flow (MBF) and MBF reserve in idiopathic dilated cardiomyopathy (IDC). STUDY DESIGN: In a double-blind, placebo-controlled trial, 16 consecutive patients with IDC were randomised to treatment with either carvedilol up to 25 mg twice a day (n = 8, 7 men, mean (SD) age 60 (9) years, mean (SD) left ventricular ejection fraction (LVEF) 30% (5%)), or placebo (n = 8, 6 men, mean (SD) age 62 (9) years, mean (SD) LVEF 28% (6%), NS vs carvedilol group). Before and 6 months after treatment, regional MBF was measured at rest and after intravenous injection of dipyridamole (Dip; 0.56 mg/kg in 4 min) by positron emission tomography and using (13)N-ammonia as a flow tracer. Exercise capacity was assessed as the time duration in a maximal bicycle exercise stress test. RESULTS: Carvedilol induced a significant decrease in heart rate at rest and during maximal exercise, and an increase in exercise capacity. Absolute MBF values did not significantly change after carvedilol or placebo treatment, either at rest or during Dip injection, although Dip-MBF tended to improve after treatment. Coronary flow reserve significantly increased following carvedilol treatment (from 1.67 (0.63) to 2.58 (1.04), p<0.001), whereas it remained unchanged following the placebo treatment (from 1.80 (0.84) to 1.77 (0.60), NS). Stress-induced regional perfusion defects decreased after carvedilol treatment (from 38% to 15%). CONCLUSIONS: Long-term treatment with carvedilol can significantly increase coronary flow reserve and reduce the occurrence of stress-induced perfusion defects, suggesting a favourable effect of the drug on coronary microvascular function in patients with IDC. |
| | |
Authors:
|
Danilo Neglia; Renata De Maria; Stefano Masi; Michela Gallopin; Patrizia Pisani; Silvia Pardini; Antonello Gavazzi; Antonio L'abbate; Oberdan Parodi |
Related Documents
:
|
3825944 - Prevalence of ischemia by quantitative thallium-201 scintigraphy in patients with ventr... 4045024 - Reversal of rest myocardial asynergy during exercise: a radionuclide scintigraphic study. 18250984 - Does partial volume corrected maximum suv based on count recovery coefficient in 3d-pet... 9527074 - Comparison of exercise electron beam computed tomography and sestamibi in the evaluatio... 3241784 - Ovarian follicular growth and maturation in the domestic pigeon and guinea fowl (numida... 12042474 - Changes in circulatory antioxidant status in horses during prolonged exercise. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-01-19 |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 93 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2007 Jul |
Date Detail:
|
Created Date: 2007-06-15 Completed Date: 2007-07-20 Revised Date: 2010-09-14 |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
|
Languages: eng Pagination: 808-13 Citation Subset: AIM; IM |
Affiliation:
|
CNR Institute of Clinical Physiology, Pisa, Italy. dneglia@ifc.cnr.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Carbazoles
/
therapeutic use* Cardiomyopathy, Dilated / drug therapy*, physiopathology Coronary Circulation / drug effects* Double-Blind Method Female Humans Male Middle Aged Positron-Emission Tomography Propanolamines / therapeutic use* Vasodilator Agents / therapeutic use* Ventricular Dysfunction, Left / physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Carbazoles; 0/Propanolamines; 0/Vasodilator Agents; 72956-09-3/carvedilol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term follow-up of patients with cardiac syndrome X treated by spinal cord stimulation.
Next Document: Incidence of fatal myocarditis: a population-based study in Finland.