| Effects of long-term high-fiber diet on macrovascular changes and lipid and glucose levels in STZ-induced diabetic SD rats. | |
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MedLine Citation:
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PMID: 1659979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of long-term high-fiber diet on lipid and glucose levels and the histological changes in the coronary arteries and thoracic aorta in STZ-induced diabetic SD rats were investigated. During the first 4 weeks of the study period, all diabetic rats were given regular chow plus water after which, all were grouped according to the following diet regimen: group II, no added cholesterol and glucomannan; group III, no added cholesterol but with glucomannan supplement, group IV, with added cholesterol but no glucomannan supplement; and group V, with both cholesterol and glucomannan supplements. 15% weight of glucomannan and 1.5% weight of cholesterol in regular rat chow were used as supplements when indicated. Non-diabetic rats which received only regular chow served as the control group (group I). In the 18th week all rats were sacrificed and weight gain, glucose, total cholesterol, HDL-cholesterol, triglyceride and lipid peroxidase concentrations were determined. Selected portions of the heart and thoracic aorta were histologically examined. Weight gain was higher in rats supplemented with glucomannan than in those without glucomannan supplements, but the difference is not significant. A lowering tendency in glucose levels was likewise observed. Furthermore, total cholesterol and HDL-cholesterol levels were lower and higher, respectively in diabetic rats receiving glucomannan. Although the triglyceride levels were similar in all rats, lipid peroxidase levels were significantly lower in rats with high-fiber diet.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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M Yoshida; J Sawa; T Hozumi; H Mimoto; Y Ishida; T Kazumi; K Doi; S Baba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 13 ISSN: 0168-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1992-01-03 Completed Date: 1992-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 147-52 Citation Subset: IM |
Affiliation:
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Hyogo Medical Center for Adults, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / pathology* Arteriosclerosis / pathology Blood Glucose / metabolism* Body Weight Cholesterol / blood* Cholesterol, Dietary / pharmacology* Cholesterol, HDL / blood* Coronary Vessels / pathology* Diabetes Mellitus, Experimental / blood, pathology, physiopathology* Dietary Carbohydrates* Dietary Fiber* Male Muscle, Smooth, Vascular / pathology Rats Rats, Inbred Strains Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Dietary Carbohydrates; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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