Document Detail

Effects of a long-term exercise program on lower limb mobility, physiological responses, walking performance, and physical activity levels in patients with peripheral arterial disease.
MedLine Citation:
PMID:  18241753     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of the study was to examine the effects of a 12-month exercise program on lower limb mobility (temporal-spatial gait parameters and gait kinematics), walking performance, peak physiological responses, and physical activity levels in individuals with symptoms of intermittent claudication due to peripheral arterial disease (PAD-IC).
METHODS: Participants (n = 21) with an appropriate history of PAD-IC, ankle-brachial pressure index (ABI) <0.9 in at least one leg and a positive Edinburgh claudication questionnaire response were prospectively recruited. Participants were randomly allocated to either a control PAD-IC group (CPAD-IC) (n = 11) that received standard medical therapy and a treatment PAD-IC group (TPAD-IC) (n = 10), which also took part in a 12-month supervised exercise program. A further group of participants (n = 11) free of PAD (ABI >0.9) and who were non-regular exercisers were recruited from the community to act as age and mass matched controls (CON). Lower limb mobility was determined via two-dimensional video motion analysis. A graded treadmill test was used to assess walking performance and peak physiological responses to exercise. Physical activity levels were measured via a 7-day pedometer recording. Differences between groups were analyzed via repeated measures analysis of variance (ANOVA).
RESULTS: The 12-month supervised exercise program had no significant effect on lower limb mobility, peak physiological responses, or physical activity levels in TPAD-IC compared with CPAD-IC participants. However, the TPAD-IC participants demonstrated significantly greater walking performance (171% improvement in pain free walking time and 120% improvement in maximal walking time compared with baseline).
CONCLUSION: The results of this study confirm that a 12-month supervised exercise program will result in improved walking performance, but does not have an impact on lower limb mobility, peak physiological responses, or physical activity levels of PAD-IC patients.
Robert G Crowther; Warwick L Spinks; Anthony S Leicht; Kunwarjit Sangla; Frank Quigley; Jonathan Golledge
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  47     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-03-13     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-9     Citation Subset:  IM    
Institute of Sport and Exercise Science, James Cook University, Townsville, Queensland, Australia. <>
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MeSH Terms
Ankle / blood supply
Blood Pressure
Brachial Artery / physiopathology
Double-Blind Method
Exercise Test
Exercise Therapy*
Intermittent Claudication / etiology*,  physiopathology,  therapy
Lower Extremity / blood supply*
Middle Aged
Motor Activity*
Peripheral Vascular Diseases / complications,  physiopathology,  therapy*
Prospective Studies
Recovery of Function
Severity of Illness Index
Time Factors
Treatment Outcome
Video Recording

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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