Document Detail


Effects of long-term ethanol consumption on adhesion molecules in liver.
MedLine Citation:
PMID:  20726338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adhesion molecules play an important role in the pathogenesis of several diseases. In this study, expression of adhesion molecules was examined in the setting of chronic alcohol induced liver damage of male albino Wistar strain rats (16-18 weeks-old, 200-220 g) in a time dependent manner. Decreased protein level and increased activities of liver marker enzymes in response to the chronic ethanol (1.6 g ethanol/kg body weight/day) exposure, indicated that these animals suffered from liver damage in a time-dependent manner. Flow cytometric analysis revealed that chronic ethanol treatment induced intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and platelet endothelial cell adhesion molecule-1 expression in liver tissues of rats with duration of ethanol exposure. The results suggest that the adhesion molecules may be associated with the initiation of hepatic injury during alcohol intoxication.
Authors:
Subir Kumar Das; Sukhes Mukherjee; D M Vasudevan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of experimental biology     Volume:  48     ISSN:  0019-5189     ISO Abbreviation:  Indian J. Exp. Biol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0233411     Medline TA:  Indian J Exp Biol     Country:  India    
Other Details:
Languages:  eng     Pagination:  394-401     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Agartala Govt. Medical College, Kunjaban P.O., Agartala 799 006, India. drsubirkdas@yahoo.co.in
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / etiology,  metabolism*
Animals
Antigens, CD31 / biosynthesis
Cell Adhesion Molecules / biosynthesis*
Ethanol / administration & dosage*,  toxicity
Flow Cytometry
Intercellular Adhesion Molecule-1 / biosynthesis
Liver / drug effects*,  metabolism,  pathology
Liver Function Tests
Male
Rats
Rats, Wistar
Time Factors
Vascular Cell Adhesion Molecule-1 / biosynthesis
Chemical
Reg. No./Substance:
0/Antigens, CD31; 0/Cell Adhesion Molecules; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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