| Effects of long-term dietary intake of magnesium on oxidative stress, apoptosis and ageing in rat liver. | |
| | |
MedLine Citation:
|
PMID: 18705541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the present study, we investigated the effect of long-term dietary Mg intake on the rate of oxidative stress, apoptosis and ageing in rat livers. To address this issue, rats were fed diets containing either a moderately deficient (0.15 g Mg/kg diet), a standard (0.8 g Mg/kg diet) or a high (3.2 g Mg/kg diet) Mg dose for two years. It is noteworthy that a higher percentage of animal mortality was observed in the lowest Mg diet, as compared to the other groups. Oxidative stress and antioxidant status were evaluated by measuring different enzyme activities, among which glutathione peroxidase activity was significantly reduced when Mg content was decreased in the diet. Moreover, we obtained an activation of caspase-3 and a higher lipid peroxidation in the Mg-deficient group, as compared to the Mg standard group, while no changes in Mg-supplemented group were observed, in accordance with our previously published data in primary cultures of rat hepatocytes (Martin et al., J Nutr 2003). Telomere shortening was measured in rat livers, as a marker of ageing. We found that telomere length was decreased in old animals, as compared to young animals confirming that telomere shortening correlated well with ageing events. Moreover, in old animals, we obtained a decrease of telomere length in the Mg-deficient group, as compared to the other groups. Taken together, our results show that a long-term chronic Mg deficiency led to oxidative stress, apoptosis and an acceleration of ageing in rat livers. |
| | |
Authors:
|
Hélène Martin; Béatrice Uring-Lambert; Markus Adrian; Abdeslam Lahlou; Alexandre Bonet; Céline Demougeot; Sylvie Devaux; Pascal Laurant; Lysiane Richert; Alain Berthelot |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Magnesium research : official organ of the International Society for the Development of Research on Magnesium Volume: 21 ISSN: 0953-1424 ISO Abbreviation: Magnes Res Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-08-18 Completed Date: 2008-11-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8900948 Medline TA: Magnes Res Country: England |
Other Details:
|
Languages: eng Pagination: 124-30 Citation Subset: IM |
Affiliation:
|
Laboratoire de Toxicologie Cellulaire, EA 2SBP, UFR des sciences médicales et pharmaceutiques, Besançon, France. helene.martin@univ-fcomte.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antioxidants / metabolism Apoptosis / drug effects* Caspase 3 / metabolism Cell Aging / drug effects Diet Glutathione Peroxidase / metabolism Liver / cytology, drug effects*, metabolism* Magnesium / administration & dosage* Magnesium Deficiency / metabolism Male Oxidative Stress / drug effects* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 7439-95-4/Magnesium; EC 1.11.1.9/Glutathione Peroxidase; EC 3.4.22.-/Casp3 protein, rat; EC 3.4.22.-/Caspase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression and functional activity of the Na/Mg exchanger, TRPM7 and MagT1 are changed to regulate M...
Next Document: Characteristics of uncontrolled hemorrhage in cardiac surgery.