Document Detail

Effects of long-term administration of pituitary-derived bovine growth hormone and estradiol on growth in steers.
MedLine Citation:
PMID:  2401657     Owner:  NLM     Status:  MEDLINE    
Sixty-three Friesian steers (9 mo old, 257 kg; n = 15 or 16/treatment) were employed in a 2 x 2 factorial to test bovine growth hormone (bGH) and estradiol (Compudose implant). Steers received daily subcutaneous injections of vehicle or bGH (40 micrograms/kg body weight) for 22 wk. Steers were slaughtered 8 wk after the end of bGH treatment (wk 30). Steers had ad libitum access to silage plus a fixed amount (4 to 5.5 kg/d) of concentrate. Average daily gain (ADG) and feed conversion efficiency (FCE) improved (P less than .05) in response both to bGH and to estradiol during wk 0 to 22. Although bGH did not affect ADG or FCE during wk 23 to 30, estradiol improved (P less than .05) them; bGH and estradiol appeared additive (nonsignificant interactions) during wk 0 to 22. At slaughter, estradiol increased (P less than .05) carcass weight and carcass and leg length while decreasing (P less than .05) conformation score and percentage of kidney, knob and channel fat (KHP); bGH decreased (P less than .05) KHP. Although both bGH and estradiol increased (P less than .01) plasma GH, their effects were not additive. Both bGH and estradiol increased (P less than .01) plasma somatomedin-C and decreased (P less than .01) plasma urea nitrogen concentrations; effects were additive. Estradiol, but not bGH, increased (P less than .05) plasma glucose, whereas neither bGH nor estradiol altered plasma creatinine and nonesterified fatty acids. In summary, both bGH and estradiol improved growth and FCE, and their effects appeared to be additive. It is likely that some of their effects were mediated by somatomedin-C.
W J Enright; J F Quirke; P D Gluckman; B H Breier; L G Kennedy; L C Hart; J F Roche; A Coert; P Allen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of animal science     Volume:  68     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-23     Completed Date:  1990-10-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2345-56     Citation Subset:  IM    
Dept. of Anim. Nutr. and Physiol., Teagasc, Grange Research Centre, Ireland.
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MeSH Terms
Blood Glucose / analysis
Blood Urea Nitrogen
Body Weight / drug effects
Cattle / growth & development*
Creatinine / blood
Estradiol / pharmacology*
Fatty Acids, Nonesterified / blood
Growth Hormone / blood,  pharmacology*
Insulin-Like Growth Factor I / analysis
Random Allocation
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 50-28-2/Estradiol; 60-27-5/Creatinine; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

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