| Effects of long-endurance running on immune system parameters and lymphocyte function in experienced marathoners. | |
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MedLine Citation:
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PMID: 2599719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The extent and duration of changes in leukocyte subsets, lymphocyte subpopulations, spontaneous blastogenesis, cortisol, and catecholamines were measured in ten experienced marathoners, who ran 3 h to exhaustion in a laboratory setting. Blood samples were taken at baseline, 1 h of exercise, and 5 min, 1.5 h, 6 h, and 21 h of recovery. The 3-h endurance run was associated with significant leukocytosis, granulocytosis, neutrophilia, monocytosis, and eosinopenia during recovery. All of these parameters except for eosinophils returned to normal by 21 h of recovery. Total lymphocyte count increased 31% at 1 h of exercise, then decreased 19% at 1.5 h of recovery when compared with baseline values. T cell count showed no significant changes, but B cell lymphocytosis was measured at 5 min and 6 h of recovery. T helper/T suppressor ratio (H/S) was significantly elevated 39% at both 1.5 h and 21 h of recovery due to the decrease in number of T suppressor cells. Spontaneous blastogenesis was significantly increased 52% by 1 h of exercise and remained elevated throughout recovery. The increase in cortisol from baseline to 1.5 h of recovery correlated positively with the increase in both total leukocyte count (r = 0.78, P = 0.008) and granulocyte count (r = 0.81, P = 0.005). Our results suggest that exhaustive endurance exercise in marathon runners is associated with many significant perturbations in immune system parameters, most of which return to normal levels at 21 h of recovery. |
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Authors:
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D C Nieman; L S Berk; M Simpson-Westerberg; K Arabatzis; S Youngberg; S A Tan; J W Lee; W C Eby |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of sports medicine Volume: 10 ISSN: 0172-4622 ISO Abbreviation: Int J Sports Med Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1990-01-30 Completed Date: 1990-01-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 317-23 Citation Subset: IM |
Affiliation:
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Department of Health Science, School of Public Health, Loma Linda University. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Catecholamines / blood, physiology Female Humans Hydrocortisone / blood, physiology Leukocytes / physiology* Lymphocyte Activation Lymphocytes / physiology* Male Physical Endurance* Running* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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