Document Detail


Effects of long-endurance running on immune system parameters and lymphocyte function in experienced marathoners.
MedLine Citation:
PMID:  2599719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The extent and duration of changes in leukocyte subsets, lymphocyte subpopulations, spontaneous blastogenesis, cortisol, and catecholamines were measured in ten experienced marathoners, who ran 3 h to exhaustion in a laboratory setting. Blood samples were taken at baseline, 1 h of exercise, and 5 min, 1.5 h, 6 h, and 21 h of recovery. The 3-h endurance run was associated with significant leukocytosis, granulocytosis, neutrophilia, monocytosis, and eosinopenia during recovery. All of these parameters except for eosinophils returned to normal by 21 h of recovery. Total lymphocyte count increased 31% at 1 h of exercise, then decreased 19% at 1.5 h of recovery when compared with baseline values. T cell count showed no significant changes, but B cell lymphocytosis was measured at 5 min and 6 h of recovery. T helper/T suppressor ratio (H/S) was significantly elevated 39% at both 1.5 h and 21 h of recovery due to the decrease in number of T suppressor cells. Spontaneous blastogenesis was significantly increased 52% by 1 h of exercise and remained elevated throughout recovery. The increase in cortisol from baseline to 1.5 h of recovery correlated positively with the increase in both total leukocyte count (r = 0.78, P = 0.008) and granulocyte count (r = 0.81, P = 0.005). Our results suggest that exhaustive endurance exercise in marathon runners is associated with many significant perturbations in immune system parameters, most of which return to normal levels at 21 h of recovery.
Authors:
D C Nieman; L S Berk; M Simpson-Westerberg; K Arabatzis; S Youngberg; S A Tan; J W Lee; W C Eby
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of sports medicine     Volume:  10     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-01-30     Completed Date:  1990-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  IM    
Affiliation:
Department of Health Science, School of Public Health, Loma Linda University.
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MeSH Terms
Descriptor/Qualifier:
Adult
Catecholamines / blood,  physiology
Female
Humans
Hydrocortisone / blood,  physiology
Leukocytes / physiology*
Lymphocyte Activation
Lymphocytes / physiology*
Male
Physical Endurance*
Running*
Time Factors
Chemical
Reg. No./Substance:
0/Catecholamines; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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