Document Detail


Effects of long-term/low-dose clarithromycin on neutrophil count and interleukin-8 level in pyometra.
MedLine Citation:
PMID:  9444409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effects of clarithromycin (CAM) on clinical and endometrial immune responses in chronic intrauterine infection (pyometra). CAM was orally administered in a dose of 200 mg once a day for 4 months (long-term/low-dose treatment) in patients with pyometra. Lavage fluid of the uterine endometrial cavity was obtained from 5 healthy women (controls) and 5 patients with pyometra to investigate the levels of neutrophil and interleukin-8 (IL-8), which is a neutrophil chemotactic factor. All patients showed clinical improvement at the end of treatment. In the assessment of the immune responses, neutrophils were accumulated in the lavage fluid of the uterine endometrial cavity in pyometra (p < 0.001, versus controls) and decreased by CAM treatment (p < 0.001). The level of IL-8 was significantly higher in the lavage fluid of patients with uterine endometritis than in the controls (p < 0.001), and decreased by CAM treatment (p < 0.01). There was a close correlation (r = 0.982) between neutrophil count and IL-8 level in the endometrial lavage of patients with pyometra. The reduction of the uterine endometrial neutrophil migration in chronic inflammatory sites may partially be a direct effect of CAM.
Authors:
H Mikamo; K Kawazoe; Y Sato; T Tamaya
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Chemotherapy     Volume:  44     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:    1998 Jan-Feb
Date Detail:
Created Date:  1998-02-27     Completed Date:  1998-02-27     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  50-4     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, School of Medicine, Gifu University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use*
Clarithromycin / therapeutic use*
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Interleukin-8 / metabolism*
Leukocyte Count / drug effects
Neutrophils / cytology,  drug effects*
Uterine Diseases / drug therapy*,  metabolism,  pathology
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Interleukin-8; 81103-11-9/Clarithromycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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