| Effects of long-term/low-dose clarithromycin on neutrophil count and interleukin-8 level in pyometra. | |
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MedLine Citation:
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PMID: 9444409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of clarithromycin (CAM) on clinical and endometrial immune responses in chronic intrauterine infection (pyometra). CAM was orally administered in a dose of 200 mg once a day for 4 months (long-term/low-dose treatment) in patients with pyometra. Lavage fluid of the uterine endometrial cavity was obtained from 5 healthy women (controls) and 5 patients with pyometra to investigate the levels of neutrophil and interleukin-8 (IL-8), which is a neutrophil chemotactic factor. All patients showed clinical improvement at the end of treatment. In the assessment of the immune responses, neutrophils were accumulated in the lavage fluid of the uterine endometrial cavity in pyometra (p < 0.001, versus controls) and decreased by CAM treatment (p < 0.001). The level of IL-8 was significantly higher in the lavage fluid of patients with uterine endometritis than in the controls (p < 0.001), and decreased by CAM treatment (p < 0.01). There was a close correlation (r = 0.982) between neutrophil count and IL-8 level in the endometrial lavage of patients with pyometra. The reduction of the uterine endometrial neutrophil migration in chronic inflammatory sites may partially be a direct effect of CAM. |
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Authors:
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H Mikamo; K Kawazoe; Y Sato; T Tamaya |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Chemotherapy Volume: 44 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 1998 Jan-Feb |
Date Detail:
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Created Date: 1998-02-27 Completed Date: 1998-02-27 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 50-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, School of Medicine, Gifu University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Anti-Bacterial Agents / therapeutic use* Clarithromycin / therapeutic use* Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Interleukin-8 / metabolism* Leukocyte Count / drug effects Neutrophils / cytology, drug effects* Uterine Diseases / drug therapy*, metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Interleukin-8; 81103-11-9/Clarithromycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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