| Effects of local intracoronary paclitaxel delivery using the Remedy transport catheter on neointimal hyperplasia after stent implantation in a porcine model. | |
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MedLine Citation:
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PMID: 21421185 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To assess the effects of local paclitaxel delivery using the Remedy catheter on neointimal hyperplasia in a porcine model and compare these results to commercially available BMS and biodegradable polymer-coated paclitaxel-eluting stents (BP-PES). METHODS AND MATERIALS: A total of 31 stents were implanted into coronary arteries of 15 domestic swine including eight BMS, six BP-PES, and 17 BMS after intravasal paclitaxel delivery at doses of 250 μg (LPD250; n=9) and 500 μg (LPD500, n=6). All stents were implanted under quantitative coronary angiography (QCA) guidance to achieve a balloon/artery diameter ratio of 1.15:1.0. Twenty-eight days after the procedure, follow-up coronary angiography was performed, the animals were euthanized, and the coronary arteries harvested for histopathological analysis. RESULTS: At follow-up, QCA analysis revealed that lumen loss was significantly worse in BMS and in both LPD groups in comparison to BP-PES stents (P=.02). Histomorphometric analysis showed that the LPD500 group presented the highest percentage of area stenosis, achieving a statistically significant difference in comparison to BMS and BP-PES stents. CONCLUSION: Our study demonstrates that local paclitaxel delivery using the Remedy transport catheter in the two studied doses (250 and 500 μg) is not effective at neointimal hyperplasia inhibition. |
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Authors:
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Krzysztof Milewski; Aleksander Zurakowski; Jacek Pajak; Lukasz Liszka; Marcin Debinski; Piotr P Buszman; Motaz Abu Samra; Piotr Dominek; Michael S Aboodi; Grzegorz L Kaluza; Pawel Buszman |
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Publication Detail:
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Type: Journal Article Date: 2010-10-20 |
Journal Detail:
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Title: Cardiovascular revascularization medicine : including molecular interventions Volume: 12 ISSN: 1878-0938 ISO Abbreviation: Cardiovasc Revasc Med Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101238551 Medline TA: Cardiovasc Revasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 82-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Upper-Silesian Center of Cardiology, Medical University of Silesia, Katowice, Poland; American Heart of Poland, Katowice, Poland; American Heart of Poland, Ustron, Poland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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