Document Detail


Effects of local delivery of Tetradecylthioacetic acid within the injured coronary vessel wall.
MedLine Citation:
PMID:  22934973     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objectives: Inflammation is involved in cell proliferation and collagen deposition causing vessel wall remodelling and restenosis after plain balloon angioplasty. Local drug delivery of bioactive agents that reduce the incidence of adverse wall remodelling is of considerable interest concerning treatment strategies for coronary vessel disease and could alter the need of repeated revascularization. Design: In this study, 34 domestic pigs undergoing coronary balloon injury were randomly assigned to Tetradecylthioacetic acid (TTA) or placebo delivered locally. After four weeks, vessel wall collagen density, inflammatory markers and lipid fractions were assessed as well as cell proliferation. Results: Collagen particle count was lower after TTA compared to placebo, 177±11 n/area versus 225±13 n/area (p=0.007). Interleukin-2 (IL-2) concentration was reduced, 1.6±0.02 pg/ml versus 2.6±0.5 pg/ml, (p=0.01). The anti-inflammatory index was increased after TTA, 46.28±12.1 versus 34.66±4.5, (p=0.025). There were no difference between TTA and placebo with regard to cell proliferation. Conclusions: Local delivery of TTA reduced the local inflammatory response and collagen accumulation. Local balloon delivery of TTA into the vessel wall may represent an alternative antiproliferative strategy for preventing restenosis, in particular for vessels with obstructive disease not available for stent implantation.
Authors:
Reidar J Pettersen; Mohamed Salem; Svein Rotevatn; Karel K J Kuiper; Terje H Larsen; Pavol Bohov; Rolf K Berge; Jan Erik Nordrehaug
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-30
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  -     ISSN:  1651-2006     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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