Document Detail


Effects of local blood flow on the percutaneous absorption of the organophosphorus compound malathion: a microdialysis study in man.
MedLine Citation:
PMID:  11570689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malathion [O,O-dimethyl-S-(1,2-dicarbethoxyethyl)phosphorodithioate] is an organophosphorus insecticide widely used in veterinary medicine and in humans for the treatment of lice. In this study, the rate of the percutaneous absorption of malathion has been measured in human skin, in vivo, using microdialysis. Malathion was detected in tissue dialysate within 30 min of its topical application to the skin of the volar surface of the forearm of healthy volunteers. The concentration of malathion in dialysate increased with lengthening duration of exposure to reach a steady state concentration at 2 h. Prolonged exposure to malathion caused a marked and long-lasting erythema localized to the area of contact. There was no evidence of local tissue oedema or of a neurogenically mediated flare or itch response following topical application. Reducing skin blood flow by the addition of the vasoconstrictor noradrenaline to the dialysis probe perfusate caused an eight-fold increase in the recovery of malathion in the dialysate, which failed to reach a steady state within 5 h. Together, these data confirm that malathion can be absorbed percutaneously and that its distribution within the cutaneous tissue space is influenced by local skin blood flow. They suggest that the increase in skin blood flow caused by malathion may itself play a significant role in enhancing its systemic uptake.
Authors:
P Boutsiouki; J P Thompson; G F Clough
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of toxicology     Volume:  75     ISSN:  0340-5761     ISO Abbreviation:  Arch. Toxicol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-09-25     Completed Date:  2002-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417615     Medline TA:  Arch Toxicol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  321-8     Citation Subset:  IM    
Affiliation:
Dermatopharmacology Unit, Allergy and Inflammation Sciences, School of Medicine, University of Southampton, UK.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adolescent
Adult
Female
Gels
Humans
Insecticides / administration & dosage,  pharmacokinetics*
Laser-Doppler Flowmetry
Malathion / administration & dosage,  pharmacokinetics*
Male
Microdialysis / methods
Norepinephrine / pharmacology
Regional Blood Flow
Skin / blood supply,  metabolism*
Skin Absorption*
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Gels; 0/Insecticides; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 121-75-5/Malathion; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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