| Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study. | |
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MedLine Citation:
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PMID: 10834859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy and safety of a loading dose regimen of three intravenous infusions with infliximab in patients with active spondyloarthropathy. METHODS: A monocentre, open-label pilot study of 21 patients with different subtypes of spondyloarthropathy was conducted. Treatment resistant patients with active disease (fulfilling inclusion criteria) received three infusions of 5 mg/kg infliximab (at weeks 0, 2, and 6). Standard clinical assessments were performed at baseline, and on days 3, 7, and 14, and from then on every two weeks. In patients who fulfilled criteria for ankylosing spondylitis, axial assessment was performed at baseline and on days 14, 42, and 84. RESULTS: In all global assessments (visual analogue scale of patient global assessment, patient pain assessment, doctor global assessment), erythrocyte sedimentation rate, and C reactive protein, a highly significant decrease could be seen already at day 3 (compared with baseline), which was maintained up to day 84. In patients with peripheral disease (n=18), tender and swollen joint count significantly decreased. In patients with axial disease (n=11), functional and disease activity indices significantly improved. Moreover in eight patients with psoriatic arthritis a significant decrease of the psoriasis area and severity index was observed. The treatment was well tolerated in all patients; no significant adverse events were seen. CONCLUSION: In this open-label pilot study of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha in patients with active spondyloarthropathy, there was a fast and significant improvement of axial and peripheral articular manifestations, without major adverse experiences. |
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Authors:
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F Van den Bosch; E Kruithof; D Baeten; F De Keyser; H Mielants; E M Veys |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 59 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-06 Completed Date: 2000-07-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 428-33 Citation Subset: IM |
Affiliation:
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Ghent University Hospital, Department of Rheumatology, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Inflammatory Agents, Non-Steroidal / therapeutic use Antibodies, Monoclonal / administration & dosage* Arthritis, Psoriatic / drug therapy Drug Therapy, Combination Evaluation Studies as Topic Female Glucocorticoids / therapeutic use Humans Male Middle Aged Patient Selection Pilot Projects Prednisolone / therapeutic use Psoriasis / drug therapy Spondylitis / drug therapy* Spondylitis, Ankylosing / drug therapy Statistics, Nonparametric Treatment Outcome Tumor Necrosis Factor-alpha / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Monoclonal; 0/Glucocorticoids; 0/Tumor Necrosis Factor-alpha; 0/infliximab; 50-24-8/Prednisolone |
| Comments/Corrections | |
Comment In:
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Ann Rheum Dis. 2000 Jun;59(6):404-7
[PMID:
10834852
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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