Document Detail


Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study.
MedLine Citation:
PMID:  10834859     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the efficacy and safety of a loading dose regimen of three intravenous infusions with infliximab in patients with active spondyloarthropathy. METHODS: A monocentre, open-label pilot study of 21 patients with different subtypes of spondyloarthropathy was conducted. Treatment resistant patients with active disease (fulfilling inclusion criteria) received three infusions of 5 mg/kg infliximab (at weeks 0, 2, and 6). Standard clinical assessments were performed at baseline, and on days 3, 7, and 14, and from then on every two weeks. In patients who fulfilled criteria for ankylosing spondylitis, axial assessment was performed at baseline and on days 14, 42, and 84. RESULTS: In all global assessments (visual analogue scale of patient global assessment, patient pain assessment, doctor global assessment), erythrocyte sedimentation rate, and C reactive protein, a highly significant decrease could be seen already at day 3 (compared with baseline), which was maintained up to day 84. In patients with peripheral disease (n=18), tender and swollen joint count significantly decreased. In patients with axial disease (n=11), functional and disease activity indices significantly improved. Moreover in eight patients with psoriatic arthritis a significant decrease of the psoriasis area and severity index was observed. The treatment was well tolerated in all patients; no significant adverse events were seen. CONCLUSION: In this open-label pilot study of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha in patients with active spondyloarthropathy, there was a fast and significant improvement of axial and peripheral articular manifestations, without major adverse experiences.
Authors:
F Van den Bosch; E Kruithof; D Baeten; F De Keyser; H Mielants; E M Veys
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  59     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-06     Completed Date:  2000-07-06     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  428-33     Citation Subset:  IM    
Affiliation:
Ghent University Hospital, Department of Rheumatology, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Antibodies, Monoclonal / administration & dosage*
Arthritis, Psoriatic / drug therapy
Drug Therapy, Combination
Evaluation Studies as Topic
Female
Glucocorticoids / therapeutic use
Humans
Male
Middle Aged
Patient Selection
Pilot Projects
Prednisolone / therapeutic use
Psoriasis / drug therapy
Spondylitis / drug therapy*
Spondylitis, Ankylosing / drug therapy
Statistics, Nonparametric
Treatment Outcome
Tumor Necrosis Factor-alpha / immunology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Monoclonal; 0/Glucocorticoids; 0/Tumor Necrosis Factor-alpha; 0/infliximab; 50-24-8/Prednisolone
Comments/Corrections
Comment In:
Ann Rheum Dis. 2000 Jun;59(6):404-7   [PMID:  10834852 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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