| Effects of lipids on intestinal adaptation following 60% resection in rats. | |
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MedLine Citation:
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PMID: 7885021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of long-chain triglycerides (LCT) and of medium-chain triglycerides (MCT) on intestinal adaptation in rats were compared following a 60% resection of intestine. Sixty Long-Evans rats were divided into four groups: control (sham-operated) rats fed an MCT-enriched diet, control rats fed an LCT-enriched diet, experimental rats fed an MCT-enriched diet, and experimental rats fed an LCT-enriched diet. In the MCT-enriched diet, 90% of the fat was MCT; in the LCT diet, 90% was LCT. In each diet, 31-32% of daily caloric intake came from fat. All diets were isocaloric and isonitrogenous. Following the 60% intestinal resection from the mid-portion of the small intestine, there were significant increases in mucosal height, villous height, villous width, and crypt depth (P < 0.05). Gut weight, mucosal weight, protein and DNA content, and DNA synthetic rate also increased. In the ileum, rats receiving the LCT diet showed greater increases in gut weight, mucosal weight, crypt depth, protein and DNA content, and DNA synthetic rate than the MCT rats did (P < 0.05). In the jejunum, however, the differences were not statistically significant. In both the jejunum and the ileum, the response of the intestine was greater closer to the anastomotic site (P < 0.05). Results of these studies demonstrated that LCT had a better effect than MCT on intestinal response both structurally and functionally. |
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Authors:
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W J Chen; C L Yang; H S Lai; K M Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of surgical research Volume: 58 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-04-13 Completed Date: 1995-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 253-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, College of Medicine, National Taiwan University, Taipei, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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drug effects* Animals DNA / metabolism Dietary Fats / pharmacology* Intestinal Mucosa / anatomy & histology, metabolism Intestines / anatomy & histology, physiology, surgery* Nitrogen / metabolism Organ Size Proteins / metabolism Rats Serum Albumin / metabolism Triglycerides / pharmacology* Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Proteins; 0/Serum Albumin; 0/Triglycerides; 7727-37-9/Nitrogen; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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