| Effects of linseed consumption for a short period of time on lipid profile and atherosclerotic lesions in rabbits fed a hypercholesterolaemic diet. | |
| | |
MedLine Citation:
|
PMID: 21791166 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Linseed contains biologically active substances, such as lignans, fibres and linoleic acid, which are believed to provide cardioprotective effects. The objective of the present study was to assess the potential hypolipaemic, anti-atherogenic and anti-inflammatory effects of linseed consumption using an experimental animal model, with rabbits fed a hypercholesterolaemic diet (1 % cholesterol extracted from lyophilised egg). A total of twenty white male rabbits were selected and divided into two groups: group I (GI), control group, ten rabbits; group II (GII), ten rabbits. The animals were fed a hypercholesterolaemic diet for 56 d. For the GII diet, ground linseed was added from day 29 through to day 56. Animals underwent aortic arch and descending aorta dissection on day 56 for histological, morphometric and immunohistochemical analysis. At the end of the experiment, GII animals presented with lower levels of total cholesterol (TC, 10 068·3 v. 16 767·0 mg/l; P < 0·05) and lower levels of LDL-cholesterol (LDL-C; 10 743·2 v. 15 961·2 mg/l; P < 0·05) when compared with the GI control group. There was no significant difference in serum HDL-cholesterol and TAG between the two groups. Almost all animals exhibited type III atherosclerotic lesions in the descending aorta. There was no statistically significant difference between the intima area and the intima:media layer area ratio in both groups. There was no difference between the positive areas for vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 molecules between the groups. Linseed consumption showed hypolipaemic action by reducing LDL-C and TC levels; however, this cholesterol-lowering effect did not reduce the atherosclerotic lesions induced by a hypercholesterolaemic diet (1 % cholesterol) for a short period of time. |
| | |
Authors:
|
Camila Rodrigues Prim; Liz Andréa Villela Baroncini; Leonardo Brandão Précoma; Pedro Henrique Lamach Caron; Guilherme Winter; Mônica Olímpia Dall'oglio Poletti; Dalton Bertolim Précoma |
Related Documents
:
|
11282146 - Nutrient preference and diet-induced adiposity in c57bl/6byj and 129p3/j mice. 3556676 - Protein synthesis inhibition and cardiac lesions associated with deoxynivalenol ingesti... 5478196 - Genetic variation of cholesterol ester content in mouse adrenals. 10611166 - Postprandial chylomicron formation and fat absorption in multidrug resistance gene 2 p-... 12791596 - Polyphenols from camellia sinenesis attenuate experimental cholestasis-induced liver fi... 19961266 - Effect of fish oils containing different amounts of epa, dha, and antioxidants on plasm... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-27 |
Journal Detail:
|
Title: The British journal of nutrition Volume: - ISSN: 1475-2662 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: 1-5 Citation Subset: - |
Affiliation:
|
Center of Health and Biological Sciences, Pontificia Universidade Católica do Paraná, Rua Imaculada Conceição, 1155, Prado Velho, CEP 80215-901 Curitiba, Paraná, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cat fertilization by mouse sperm injection.
Next Document: Effect of oocyte-secreted factors on porcine in vitro maturation, cumulus expansion and developmenta...