Document Detail

Effects of limb elevation and increased intramuscular pressure on human tibialis anterior muscle blood flow.
MedLine Citation:
PMID:  11718286     Owner:  NLM     Status:  MEDLINE    
The effects of limb elevation and increased intramuscular pressure (IMP) on blood flow in the tibialis anterior muscle and leg neuromuscular function were studied in eight healthy subjects. Muscle blood flow (MBF) was measured by photoplethysmography using a custom-designed probe. IMP was elevated bilaterally by vein obstruction (60-65 mmHg) lasting 30 min induced by a thigh tourniquet of casted legs. Skin sensibility of the feet and the amplitude and area of the compound muscle action potentials from the extensor digitorum brevis muscle were evaluated. The subject kept one leg elevated 32 cm above heart level and the contralateral leg at heart level. All recordings were made before, during and after vein obstruction. IMP increased to 40 mmHg in the vein-obstructed casted legs. Perfusion pressure decreased from [mean (SD)] 42 (5.8) mmHg to 17 (6.4) mmHg in the elevated leg and from 65 (9.9) mmHg to 43 (8.4) mmHg in the non-elevated leg. MBF decreased by 50% in the elevated leg and by 42% in the non-elevated leg. Subjects experienced sensory dysfunction and muscular weakness in the elevated leg. In conclusion, increased IMP, induced by venous obstruction of a casted leg, reduced perfusion pressure and MBF, and resulted in a diminished amplitude and area of the compound muscle action potentials. Limb elevation above heart level combined with venous stasis of a casted leg further reduced perfusion pressure and MBF, and induced sensory dysfunction and muscular weakness.
Q Zhang; J Styf; L G Lindberg
Related Documents :
8330606 - Vascular adjustment and fluid reabsorption in the human forearm during elevation.
17240736 - Central venous pressure: an old lady in new clothes?
9270586 - Increased intra-abdominal pressure and cardiac filling pressures in obesity-associated ...
11039356 - Modification of a previously described arteriovenous malformation model in the swine: e...
7333196 - Hemodynamic correlates of autonomic reflexes in patients with labile and fixed hyperten...
1189986 - Factors related to blood pressure in a general population sample of swedish men.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology     Volume:  85     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-22     Completed Date:  2002-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  567-71     Citation Subset:  IM    
Department of Orthopaedics, Sahlgrenska University Hospital, Göteborg, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Action Potentials / physiology
Blood Volume / physiology
Casts, Surgical
Motor Neurons / physiology
Muscle Weakness / physiopathology
Muscle, Skeletal / blood supply*,  innervation,  physiology
Posture / physiology*
Regional Blood Flow / physiology
Veins / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Localization of diaphragm motor cortical representation and determination of corticodiaphragmatic la...
Next Document:  Thermal stability of the human body under hyperbaric environmental conditions: a theoretical study.