| Effects of light ethanol consumption during pregnancy: increased frequency of minor anomalies in the newborn and altered contractility of umbilical cord artery. | |
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MedLine Citation:
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PMID: 17515871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study explores the effects of light maternal ethanol consumption during pregnancy on the appearance of minor malformations in neonates as well as on the contractile properties of their umbilical cord arteries (UCAs). Clinical external findings of newborns of women declaring light ethanol consumption during any period of their pregnancies [ethanol-exposed group (E group), n=79] were compared with those of nonexposed mothers [nonexposed to ethanol group (NE group), n=100]. Women who smoked or had any associated pathology were excluded. E group mothers consumed, on average, 200-250 mL ethanol/trimester (upper limit 700 mL/trimester). Sixty-six percent of the neonates in the E group presented at least one minor malformation (retromicrognathia and minor anomalies of the auricular/preauricular area were the more common), whereas only 16% of the NE group did (p=0.0000). The percentage of children exhibiting Apgar scores <7 was significantly greater in the E group (11% versus 2%, p=0.0119). UCAs from the E group developed significantly less contractile force (p<0.05) than those of the NE group when exposed to 1 microM serotonin (5-HT) or to a high K+ depolarizing solution. This difference persisted after inhibition of endothelial release of nitric oxide (NO) and prostacyclin. In conclusion, even light drinking should be considered a risk during pregnancy. |
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Authors:
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María Florencia Iveli; Silvina Morales; Alejandro Rebolledo; Valeria Savietto; Silvia Salemme; María Apezteguía; Norma Cecotti; Ricardo Drut; Verónica Milesi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 61 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-05-22 Completed Date: 2007-06-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 456-61 Citation Subset: IM |
Affiliation:
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Departamento de Ciencias Biológicas, Universidad Nacional de La Plata, La Plata, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alcohol Drinking / adverse effects* Ear / abnormalities Female Humans Maternal-Fetal Exchange / drug effects*, physiology* Micrognathism / chemically induced Nose / abnormalities Pregnancy Prenatal Exposure Delayed Effects / chemically induced*, physiopathology Random Allocation Umbilical Arteries / drug effects*, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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