Document Detail

Effects of light and darkness on cell deaths in damaged retinal ganglion cells of the carp retina.
MedLine Citation:
PMID:  11512415     Owner:  NLM     Status:  MEDLINE    
Effects of light and darkness on the apoptosis of retinal ganglion cells (RGCs) in young carp were measured by TUNEL method after transection of the optic nerve. Following the operation, the fish were kept under one of four regimens; constant darkness (DD), constant light (LL), 12 hr light and 12 hr dark (LD) and 3 hr of flickering light followed by 21 hr in the dark (FL). On day 3, the highest ratio of apoptotic RGCs was seen under conditions of DD, followed by LL, LD, and FL. On day 6, the percentages of apoptotic RGCs were lower under every experimental condition than what they had been earlier on day 3, but the same ranking order was maintained. Immunohistochemically it could be shown that phosphorylated ERKs were more intensively localized in FL rather than DD retinas. The results suggest that illumination regimens, and in particular cyclic diurnal light/dark changes, have an influence on the degree of apoptosis of damaged RGCs, and that inhibition of apoptosis is correlated with the higher expression of phosphorylated ERKs.
M Dezawa; X Mo; T Oshitari; M Takano; V B Meyer-Rochow; H Sawada; E Eguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurobiologiae experimentalis     Volume:  61     ISSN:  0065-1400     ISO Abbreviation:  Acta Neurobiol Exp (Wars)     Publication Date:  2001  
Date Detail:
Created Date:  2001-08-21     Completed Date:  2001-09-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  1246675     Medline TA:  Acta Neurobiol Exp (Wars)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Department of Anatomy, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
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MeSH Terms
Adaptation, Ocular / physiology*
Apoptosis / physiology*
Dark Adaptation / physiology*
Fluorescent Antibody Technique
In Situ Nick-End Labeling
Mitogen-Activated Protein Kinases / metabolism
Optic Nerve Injuries / pathology*,  physiopathology
Photic Stimulation
Retinal Ganglion Cells / enzymology,  pathology*
Reg. No./Substance:
EC Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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