Document Detail


Effects of light cues on re-entrainment of the food-dominated peripheral clocks in mammals.
MedLine Citation:
PMID:  18538509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the light/dark (LD) cycle is a weak Zeitgeber in peripheral clocks compared with food stimuli, whether the effect of light cues on the re-entrainment of peripheral clocks can be masked by that of the dominating food cue remains unknown. In the present study, the individual reversal of LD cycle for 7 days could not obviously affect circadian patterns of core clock genes (Bmal1, Cry1, Per1, and Dec1) in the liver and heart of restricted-fed rats. In contrast, reversing the feeding schedule together with the LD cycle markedly enhanced the re-entrainment of peripheral clocks compared with reversal of the feeding regimen alone. In addition, LD reversal alone for 7 days contrarily regulated the expression levels of Cry1, Per1, and Dec1 in the liver and heart. Moreover, daytime restricted feeding not only induced different phase shift rates of the four examined clock genes but also led to reversed phase shift direction in their resetting processes in these two peripheral clocks. Furthermore, the resetting sequences of these genes were also disparate between these two peripheral clocks. These observations suggest that the mechanisms underlying the liver and heart clocks are distinct, which may distinguish them from each other in the SCN-synchronized peripheral system.
Authors:
Tao Wu; Yuanxiang Jin; Yinhua Ni; Danping Zhang; Hisanori Kato; Zhengwei Fu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-27
Journal Detail:
Title:  Gene     Volume:  419     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-09-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  27-34     Citation Subset:  IM    
Affiliation:
College of Biological and Environmental Engineering, Zhejiang University of Technology, China.
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MeSH Terms
Descriptor/Qualifier:
ARNTL Transcription Factors
Animals
Basic Helix-Loop-Helix Transcription Factors / genetics,  metabolism
Biological Clocks / genetics*
Cell Cycle Proteins / genetics,  metabolism
Circadian Rhythm / genetics*
Cryptochromes
Cues
Eating*
Flavoproteins / genetics,  metabolism
Gene Expression Regulation*
Homeodomain Proteins / genetics,  metabolism
Light*
Liver / metabolism
Male
Myocardium / metabolism
Period Circadian Proteins
RNA, Messenger / metabolism
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/ARNTL Transcription Factors; 0/Basic Helix-Loop-Helix Transcription Factors; 0/Bhlhb2 protein, rat; 0/Cell Cycle Proteins; 0/Cry1 protein, rat; 0/Cryptochromes; 0/Flavoproteins; 0/Homeodomain Proteins; 0/Per1 protein, rat; 0/Period Circadian Proteins; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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