| Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome. | |
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MedLine Citation:
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PMID: 21196367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabolic syndrome (MetS) is a clustering of cardiovascular risk factors which places individuals at increased risk for cardiovascular morbidity and mortality. In addition to obesity and insulin resistance, inflammation is emerging as a potential etiologic factor of the syndrome. One hypothesis suggests that obesity contributes to insulin resistance through increased production of adipose-derived inflammatory cytokines. Currently, lifestyle change is the first line of treatment for MetS. Only recently, however, have studies begun exploring the effect of lifestyle interventions on the mediation of inflammation in individuals with MetS. This review summarizes the strongest evidence (i.e. randomized controlled trial data) for a role of lifestyle interventions (diet and/or exercise) on the improvement of inflammatory biomarkers in people with MetS. Of six studies assessed, lifestyle interventions were consistently successful at improving the inflammatory and metabolic profiles. Interestingly, improvements in the inflammatory profile were found to be largely independent of obesity. Data currently suggest that alterations in dietary composition may be the most effective lifestyle change, although there is a need for more research in this area. |
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Authors:
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Kristen M Beavers; Barbara J Nicklas |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-01-01 |
Journal Detail:
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Title: Frontiers in bioscience (Scholar edition) Volume: 3 ISSN: 1945-0524 ISO Abbreviation: Front Biosci (Schol Ed) Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-03 Completed Date: 2011-05-17 Revised Date: 2012-05-04 |
Medline Journal Info:
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Nlm Unique ID: 101485241 Medline TA: Front Biosci (Schol Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 168-77 Citation Subset: IM |
Affiliation:
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J. Paul Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest, University School of Medicine, Winston-Salem, North Carolina 27157, USA. kbeavers@wfubmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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metabolism C-Reactive Protein / metabolism Cytokines / metabolism Fibrinogen / metabolism Humans Inflammation / diet therapy, epidemiology, therapy* Leukocyte Count Metabolic Syndrome X / diet therapy, epidemiology, therapy* Prevalence Risk Reduction Behavior* |
| Grant Support | |
ID/Acronym/Agency:
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AG027529/AG/NIA NIH HHS; HL093713/HL/NHLBI NIH HHS; R01 AG027529-01A1/AG/NIA NIH HHS; R01 AG027529-02/AG/NIA NIH HHS; R01 AG027529-03/AG/NIA NIH HHS; R01 AG027529-04/AG/NIA NIH HHS; R01 HL093713/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cytokines; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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