Document Detail

Effects of liandou qingmai recipe (see text) on endothelin-1, nitric oxide, interleukin-6 and interleukin-10 levels in patients with coronary heart disease.
MedLine Citation:
PMID:  21977856     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To observe effects of Liandou Qingmai Recipe (see text) on endothelin-1 (ET-1), nitric oxide (NO), interleukin-6 (IL-6) and IL-10 levels in patients with coronary heart disease.
METHODS: Total 101 cases with coronary heart disease were randomly divided into a treatment group (n = 45) treated by Liandou Qingmai Recipe and a standard treatment group (control group, n = 56), with a normal group of 16 health persons set up. Changes of ET-1, NO, IL-6 and IL-10 levels were measured before treatment and after treatment for two weeks. And the data were analyzed by SPSS 16.0 statistic software.
RESULTS: Before treatment, the levels of ET-1, IL-6 and IL-10 levels were significantly higher and NO was significantly lower in the patients with coronary heart disease than those in the normal group (90.7 +/- 12.7 ng/L vs 41.8 +/- 13.5 ng/L, 9.17 +/- 0.18 ng/L vs 1.10 +/- 0.08 ng/L, 1.94 +/- 0.26 ng/L vs 1.09 +/- 0.06 ng/L, and 92.2 +/- 17.7 micromol/L vs 124.5 +/- 27.2 micromol/L; all P < 0.05), with no significant differences in the levels of ET-1, NO, IL-6 and IL-10 between the treatment group and the control group (P > 0.05); After treatment, ET-1 and IL-6 significantly decreased in the treatment group and the control group, and NO increased in the treatment group; And IL-6 level was significantly lower and NO level was higher in the treatment group than those in the control group (4.48 +/- 1.22 ng/L vs 5.13 +/- 1.85 ng/L, 117.4 +/- 22.3 micromol/L vs 92.4 +/- 17.1 micromol/L; both P < 0.05); There was a positive correlation between IL-6 and IL-10, and a negative correlation between NO and IL-10 (r = 0.142, r = -0.152; both P < 0.05).
CONCLUSION: Liandou Qingmai Recipe can decline IL-6, IL-10 and ET-1 levels, and raise NO level in patients with coronary heart disease on the basis of standard treatment, so as to inhibit endothelial inflammatory response, improve vascular endothelial function, with stronger anti-AS action; And vascular endothelial lesion is related with inflammatory response.
Hong-Jun Zhu; Shu Lu; Wei Su; Shao-Yu Gong; Zhi-Bin Zhang; Ping Li; Hui-Yuan Wei; Qing-You Yang; Hong Tang; Cheng-Xia Xia; Ming Zhu
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine     Volume:  31     ISSN:  0255-2922     ISO Abbreviation:  J Tradit Chin Med     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-07     Completed Date:  2011-11-02     Revised Date:  2012-01-05    
Medline Journal Info:
Nlm Unique ID:  8211546     Medline TA:  J Tradit Chin Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Heart Internal Medicine Department, Wuxi Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangsu 214001, China.
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MeSH Terms
Aged, 80 and over
Coronary Disease / blood*,  drug therapy*
Drugs, Chinese Herbal / therapeutic use*
Endothelin-1 / blood*
Interleukin-10 / blood*
Interleukin-6 / blood*
Middle Aged
Nitric Oxide / blood*
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Endothelin-1; 0/Interleukin-6; 10102-43-9/Nitric Oxide; 130068-27-8/Interleukin-10

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