| Effects of liandou qingmai recipe (see text) on endothelin-1, nitric oxide, interleukin-6 and interleukin-10 levels in patients with coronary heart disease. | |
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MedLine Citation:
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PMID: 21977856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To observe effects of Liandou Qingmai Recipe (see text) on endothelin-1 (ET-1), nitric oxide (NO), interleukin-6 (IL-6) and IL-10 levels in patients with coronary heart disease. METHODS: Total 101 cases with coronary heart disease were randomly divided into a treatment group (n = 45) treated by Liandou Qingmai Recipe and a standard treatment group (control group, n = 56), with a normal group of 16 health persons set up. Changes of ET-1, NO, IL-6 and IL-10 levels were measured before treatment and after treatment for two weeks. And the data were analyzed by SPSS 16.0 statistic software. RESULTS: Before treatment, the levels of ET-1, IL-6 and IL-10 levels were significantly higher and NO was significantly lower in the patients with coronary heart disease than those in the normal group (90.7 +/- 12.7 ng/L vs 41.8 +/- 13.5 ng/L, 9.17 +/- 0.18 ng/L vs 1.10 +/- 0.08 ng/L, 1.94 +/- 0.26 ng/L vs 1.09 +/- 0.06 ng/L, and 92.2 +/- 17.7 micromol/L vs 124.5 +/- 27.2 micromol/L; all P < 0.05), with no significant differences in the levels of ET-1, NO, IL-6 and IL-10 between the treatment group and the control group (P > 0.05); After treatment, ET-1 and IL-6 significantly decreased in the treatment group and the control group, and NO increased in the treatment group; And IL-6 level was significantly lower and NO level was higher in the treatment group than those in the control group (4.48 +/- 1.22 ng/L vs 5.13 +/- 1.85 ng/L, 117.4 +/- 22.3 micromol/L vs 92.4 +/- 17.1 micromol/L; both P < 0.05); There was a positive correlation between IL-6 and IL-10, and a negative correlation between NO and IL-10 (r = 0.142, r = -0.152; both P < 0.05). CONCLUSION: Liandou Qingmai Recipe can decline IL-6, IL-10 and ET-1 levels, and raise NO level in patients with coronary heart disease on the basis of standard treatment, so as to inhibit endothelial inflammatory response, improve vascular endothelial function, with stronger anti-AS action; And vascular endothelial lesion is related with inflammatory response. |
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Authors:
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Hong-Jun Zhu; Shu Lu; Wei Su; Shao-Yu Gong; Zhi-Bin Zhang; Ping Li; Hui-Yuan Wei; Qing-You Yang; Hong Tang; Cheng-Xia Xia; Ming Zhu |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine Volume: 31 ISSN: 0255-2922 ISO Abbreviation: J Tradit Chin Med Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-07 Completed Date: 2011-11-02 Revised Date: 2012-01-05 |
Medline Journal Info:
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Nlm Unique ID: 8211546 Medline TA: J Tradit Chin Med Country: China |
Other Details:
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Languages: eng Pagination: 173-7 Citation Subset: IM |
Affiliation:
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Heart Internal Medicine Department, Wuxi Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangsu 214001, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Coronary Disease / blood*, drug therapy* Drugs, Chinese Herbal / therapeutic use* Endothelin-1 / blood* Female Humans Interleukin-10 / blood* Interleukin-6 / blood* Male Middle Aged Nitric Oxide / blood* |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/Endothelin-1; 0/Interleukin-6; 10102-43-9/Nitric Oxide; 130068-27-8/Interleukin-10 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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