| Effects of levosimendan versus dobutamine on left atrial function in decompensated heart failure. | |
| | |
MedLine Citation:
|
PMID: 19812809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Although the effects of levosimendan on the left ventricle (LV) have been studied, its effect on left atrial (LA) function is poorly understood, despite its key role in optimizing LV function. OBJECTIVE: To compare the effects of levosimendan and dobutamine on LA and LV function in patients with decompensated heart failure (DHF). METHODS: Seventy-four patients (mean [+/- SD] age 64+/-10 years) with DHF and an LV ejection fraction of 35% or lower were randomly assigned to receive levosimendan (n=37) or dobutamine (n=37). LA active emptying fraction, LA passive emptying fraction (PEF) and the ratio of mitral inflow early diastolic velocity to annulus velocity (E/e) were evaluated with pulsed wave and tissue Doppler imaging along with plasma B-type natriuretic peptide (BNP) level measurements before and after drug infusion. RESULTS: The ejection fraction was significantly increased in both groups. The levosimendan group had a greater decrease in BNP and a greater increase in active emptying fraction at 24 h compared with the dobutamine group. The PEF, E/e and deceleration time of the E wave were significantly improved in the levosimendan group, but not in the dobutamine group. Levosimendan- induced percentage change of BNP was significantly correlated with the percentage change of E/e and PEF (r=0.48 [P<0.005] and r=-0.38 [P<0.05], respectively). CONCLUSIONS: In patients with DHF, levosimendan and dobutamine both improve LV systolic function. However, levosimendan also improves LV diastolic function and LA performance in parallel with a greater improvement in neurohormonal activation compared with dobutamine. |
| | |
Authors:
|
Duman Duman; Fatih Palit; Ergun Simsek; Karadag Bilgehan; Atalay Sacide |
Related Documents
:
|
2614869 - Determinants of late potentials in myocardial infarction. 11755299 - Diastolic heart failure: neglected or misdiagnosed? 7074779 - Effects of prazosin on coronary and left ventricular dynamics in conscious dogs. 19755919 - Postinfarct treatment with oxytocin improves cardiac function and remodeling via activa... 17901889 - Relation of b-type natriuretic peptide to left ventricular wall stress as assessed by c... 9396419 - Cardiovascular death and left ventricular remodeling two years after myocardial infarct... 9674489 - Commotio cordis: cardiovascular manifestations of a rare survivor. 6650949 - Left bundle branch block associated with propoxyphene hydrochloride poisoning. 1430679 - Mechanism of benefit of combination thrombolytic therapy for acute myocardial infarctio... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The Canadian journal of cardiology Volume: 25 ISSN: 1916-7075 ISO Abbreviation: Can J Cardiol Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-10-08 Completed Date: 2009-10-27 Revised Date: 2010-10-04 |
Medline Journal Info:
|
Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: Canada |
Other Details:
|
Languages: eng Pagination: e353-6 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey. drduman@excite.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Atrial Function, Left / drug effects*, physiology Cardiotonic Agents / administration & dosage, therapeutic use* Dobutamine / administration & dosage, therapeutic use* Dose-Response Relationship, Drug Echocardiography Electrocardiography Female Follow-Up Studies Heart Failure / drug therapy*, physiopathology, ultrasonography Humans Hydrazones / administration & dosage, therapeutic use* Infusions, Intravenous Male Middle Aged Prospective Studies Pyridazines / administration & dosage, therapeutic use* Single-Blind Method Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 0/Hydrazones; 0/Pyridazines; 131741-08-7/simendan; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Factors related to time to admission to specialized multidisciplinary clinics in patients with conge...
Next Document: A sweet tooth as the root cause of cardiac arrest.