| Effects of levosimendan on TNF-alpha, BNP and MMP-1 in patients with heart failure with anemia. | |
| | |
MedLine Citation:
|
PMID: 22735864 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Levosimendan is known with its two-sided effects of strengthening myofibril contraction without increasing myocardial oxygen demand. Anemia is a deteriorating situation that causes increase of drug dosing in patients with heart failure. OBJECTIVES: In this study, we compared the effectiveness of levosimendan treatment in decompensated heart failure patients with or without anemia. METHODS: Twenty-three anemic patients having class 3 or 4 heart failure according to New York Heart Association (NYHA) and an ejection fraction of below 35% were included to the study. Another 23 patients with the same cardiac diagnosis but without anemia served as control group. Twenty-four hours levosimendan treatment was added to the traditional heart failure treatment of these patients. Samples were taken to measure serum tumor necrotizing factor alpha (TNF-alpha), aminoterminal pro-brain natriuretic peptide (NT-proBNP) and matrix metalloproteinase-1 (MMP-1) levels before and after the administration. RESULTS: There was no significant difference between serum TNF-alpha and MMP-1 levels before and after the treatment (p>0.05). Although NT-proBNP level decreased in both groups after the treatment this was not statistically significant (p=0.531 and p=0.913 for anemia and control groups respectively). Significant restoration of functional capacity was seen in both groups assessed according to NYHA (p<0.001 and p=0.001 for anemia and control groups respectively). CONCLUSION: Levosimendan treatment shows similar effects in heart failure patients with anemia to that of patients without anemia. However, the early effect of this treatment on TNF-alpha, NT-proBNP and MMP-1 levels is not evident. It provides significant improvement in functional capacity without influence from anemia. |
| | |
Authors:
|
Mutlu Büyüklü; Akif Turhan Kürüm; Ersan Tatlý; Turan Set |
Related Documents
:
|
8145354 - Fatal and nonfatal methamphetamine intoxication in the intensive care unit. 19788144 - Acute poisoning with tricholoma equestre. 1127994 - Carotid endarterectomy. complications and preoperative assessment of risk. 8859064 - Treatment of wilson disease with ammonium tetrathiomolybdate. ii. initial therapy in 33... 17265494 - Autoantibodies to rna helicase a: a new serologic marker of early lupus. 6744584 - Concentrations of ag, al, au, bi, cd, cu, pb, sb, and se in cerebrospinal fluid of pati... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-26 |
Journal Detail:
|
Title: Arquivos brasileiros de cardiologia Volume: - ISSN: 1678-4170 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421031 Medline TA: Arq Bras Cardiol Country: - |
Other Details:
|
Languages: ENG; POR Pagination: - Citation Subset: - |
Affiliation:
|
Departamento de Cardiologia, Hospital Estadual de Erzincan, Erzincan. |
Vernacular Title:
|
Efeitos do levosimendan sobre TNF-alfa, PNB e MMP-1 em pacientes com insuficiência cardíaca com anemia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of creatine supplementation on the functional capacity of patients with Heart Failure.
Next Document: Previous percutaneous coronary intervention as risk factor for coronary artery bypass grafting.