| Effects of levodopa and bromocriptine on blood pressure and plasma catecholamines in parkinsonians. | |
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MedLine Citation:
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PMID: 2029695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood pressure (BP), heart rate (HR), plasma noradrenaline (NA), and adrenaline (A) levels in the lying and standing position were compared in patients with Parkinson's disease (PD) and control subjects. Three groups of PD patients (stage 2 and 3) were investigated: six patients deprived of antiparkinsonian drugs from 48 h, seven levodopa + benserazide-treated patients, and seven bromocriptine-treated patients. BP, HR, NA, and A were similar at rest and in the standing position in controls and in PD patients deprived of antiparkinsonian drugs from 48 h. Chronic treatment with levodopa (+ benserazide) failed to modify BP, HR, NA, and A. Bromocriptine decreased BP, HR, and NA (but not A) at rest. In PD patients treated with levodopa (+ benserazide) or bromocriptine alone, the rise in NA (but not A) elicited by standing up was reduced. These results indicate that (a) stages 2 to 3 of Parkinson's disease are not accompanied by major changes in autonomic cardiovascular function and (b) dopaminergic drugs blunted the sympathetic response to standing up. |
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Authors:
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G Durrieu; J M Senard; M A Tran; A Rascol; J L Montastruc |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical neuropharmacology Volume: 14 ISSN: 0362-5664 ISO Abbreviation: Clin Neuropharmacol Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-06-18 Completed Date: 1991-06-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7607910 Medline TA: Clin Neuropharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 84-90 Citation Subset: IM |
Affiliation:
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Department of Medical Pharmacology, INSERM U317, Faculté de Médecine, Toulouse, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure / drug effects* Bromocriptine / pharmacology* Epinephrine / blood* Female Humans Levodopa / pharmacology* Male Middle Aged Norepinephrine / blood* Parkinson Disease / blood*, drug therapy, physiopathology Posture / physiology |
| Chemical | |
Reg. No./Substance:
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0/Levodopa; 25614-03-3/Bromocriptine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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