Document Detail

Effects of levodopa and bromocriptine on blood pressure and plasma catecholamines in parkinsonians.
MedLine Citation:
PMID:  2029695     Owner:  NLM     Status:  MEDLINE    
Blood pressure (BP), heart rate (HR), plasma noradrenaline (NA), and adrenaline (A) levels in the lying and standing position were compared in patients with Parkinson's disease (PD) and control subjects. Three groups of PD patients (stage 2 and 3) were investigated: six patients deprived of antiparkinsonian drugs from 48 h, seven levodopa + benserazide-treated patients, and seven bromocriptine-treated patients. BP, HR, NA, and A were similar at rest and in the standing position in controls and in PD patients deprived of antiparkinsonian drugs from 48 h. Chronic treatment with levodopa (+ benserazide) failed to modify BP, HR, NA, and A. Bromocriptine decreased BP, HR, and NA (but not A) at rest. In PD patients treated with levodopa (+ benserazide) or bromocriptine alone, the rise in NA (but not A) elicited by standing up was reduced. These results indicate that (a) stages 2 to 3 of Parkinson's disease are not accompanied by major changes in autonomic cardiovascular function and (b) dopaminergic drugs blunted the sympathetic response to standing up.
G Durrieu; J M Senard; M A Tran; A Rascol; J L Montastruc
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  14     ISSN:  0362-5664     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-06-18     Completed Date:  1991-06-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Department of Medical Pharmacology, INSERM U317, Faculté de Médecine, Toulouse, France.
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MeSH Terms
Blood Pressure / drug effects*
Bromocriptine / pharmacology*
Epinephrine / blood*
Levodopa / pharmacology*
Middle Aged
Norepinephrine / blood*
Parkinson Disease / blood*,  drug therapy,  physiopathology
Posture / physiology
Reg. No./Substance:
0/Levodopa; 25614-03-3/Bromocriptine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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