Document Detail

Effects of leukotrienes on the electroretinographic profile of the isolated rat retina.
MedLine Citation:
PMID:  2993185     Owner:  NLM     Status:  MEDLINE    
The isolated retina represents an excellent membrane model since it provides a specific electrophysiological response that is easy to quantify. Therefore the authors have tested the effects of B4, C4 and D4 leukotrienes on this model. In the presence of leukotrienes, electrical response generally decreases and survival duration of the isolated retina is generally shortened. No significant difference between the effects of the three tested products has been found. These results are discussed in relation to, on the one hand, the mechanism of intraretinal generation of its electrophysiological signal and, on the other hand, the leukotrienes' role in inflammatory diseases of the retina.
M Doly; P Braquet; B Bonhomme; J C Vennat; G Meyniel
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  International journal of tissue reactions     Volume:  7     ISSN:  0250-0868     ISO Abbreviation:  Int J Tissue React     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302116     Medline TA:  Int J Tissue React     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
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MeSH Terms
Leukotriene B4 / pharmacology*
Retina / drug effects*
SRS-A / pharmacology*
Reg. No./Substance:
0/SRS-A; 71160-24-2/Leukotriene B4

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