Document Detail

Effects of leukotrienes C4, D4, and E4 on cerebral arteries of newborn pigs.
MedLine Citation:
PMID:  3022226     Owner:  NLM     Status:  MEDLINE    
We examined effects of topical application of leukotrienes (LT) C4, D4, and E4 on cerebral arteries of newborn pigs in vivo. Diameters of pial arteries were measured using a cranial window method during application of artificial cerebrospinal fluid without drug, and cerebrospinal fluid containing LT C4, D4, and E4 (1, 10, 100, 1000, and 5000 ng/ml). Control diameters ranged from 51-345 micron. All three LT constricted pial arteries in a dose-dependent manner, with a threshold for detectable response at 10 ng/ml (7 +/- 3% for LTD4). The magnitude of constrictor response at the highest dose was 23 +/- 3% for LTC4, 17 +/- 2% for LTD4, and 17 +/- 3% for LTE4. The specific receptor antagonist FPL 55712 blocked the constrictor response to LT. We conclude that LT are potent constrictors of cerebral arteries in newborn pigs.
D W Busija; C W Leffler; D G Beasley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  20     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-11-28     Completed Date:  1986-11-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  973-6     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / physiology*
Cerebral Arteries / drug effects*,  physiology
Chromones / pharmacology
Clonidine / pharmacology
Dose-Response Relationship, Drug
Leukotriene E4
SRS-A / analogs & derivatives,  antagonists & inhibitors,  pharmacology*
Vasoconstriction / drug effects*
Grant Support
Reg. No./Substance:
0/Chromones; 0/SRS-A; 40786-08-1/FPL 55712; 4205-90-7/Clonidine; 75715-89-8/Leukotriene E4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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