Document Detail

Effects of leukaemia inhibitory factor on endometrial receptivity and its hormonal regulation in rabbits.
MedLine Citation:
PMID:  11589623     Owner:  NLM     Status:  MEDLINE    
The effects of hormones on production of leukaemia inhibitory factor (LIF) and the uterine receptivity in rabbits were studied. In ovariectomised rabbits, LIF protein was not detected in control but upregulated by progesterone alone. Oestrogen had a slightly negative effect when the rabbits were treated with both oestrogen and progesterone. Mifepristone (Mi) inhibited the progesterone-stimulated production of LIF in rabbit uterus. The transfer of embryos to LIF-treated recipients significantly increased pregnancy rate (70%) and implantation rate (27%) as compared with control (pregnancy rate=40% and implantation rate=17%). The transfer of embryos to LIF and mifepristone-treated recipients significantly decreased pregnancy rate (30%) and implantation rate (9%). The results indicated that LIF protein had a beneficial effect on uterine receptivity and mifepristone prevented this effect.
C Q Liu; Y Yuan; Z X Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international     Volume:  25     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2001  
Date Detail:
Created Date:  2001-10-08     Completed Date:  2001-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1029-32     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Shanghai Institute of Planned Parenthood Research, Shanghai, P. R. China.
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MeSH Terms
Animal Population Groups
Embryo Implantation / drug effects*
Endometrium / drug effects,  physiology*
Estradiol / pharmacology
Gonadal Steroid Hormones / pharmacology*
Growth Inhibitors / metabolism,  pharmacology*
Leukemia Inhibitory Factor
Lymphokines / metabolism,  pharmacology*
Mifepristone / pharmacology
Pregnancy, Animal / drug effects,  physiology*
Progesterone / pharmacology
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Growth Inhibitors; 0/Interleukin-6; 0/Leukemia Inhibitory Factor; 0/Lymphokines; 50-28-2/Estradiol; 57-83-0/Progesterone; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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