Document Detail


Effects of leukaemia inhibitory factor on endometrial receptivity and its hormonal regulation in rabbits.
MedLine Citation:
PMID:  11589623     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of hormones on production of leukaemia inhibitory factor (LIF) and the uterine receptivity in rabbits were studied. In ovariectomised rabbits, LIF protein was not detected in control but upregulated by progesterone alone. Oestrogen had a slightly negative effect when the rabbits were treated with both oestrogen and progesterone. Mifepristone (Mi) inhibited the progesterone-stimulated production of LIF in rabbit uterus. The transfer of embryos to LIF-treated recipients significantly increased pregnancy rate (70%) and implantation rate (27%) as compared with control (pregnancy rate=40% and implantation rate=17%). The transfer of embryos to LIF and mifepristone-treated recipients significantly decreased pregnancy rate (30%) and implantation rate (9%). The results indicated that LIF protein had a beneficial effect on uterine receptivity and mifepristone prevented this effect.
Authors:
C Q Liu; Y Yuan; Z X Wang
Related Documents :
21122603 - Effect of first-trimester ultrasound screening for down syndrome on maternal-fetal atta...
2387753 - Changes induced by progesterone treatment in the sulphatides of the frog oviduct.
17162943 - Efficacy of four trap types for detecting and monitoring culex spp. in north central fl...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international     Volume:  25     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2001  
Date Detail:
Created Date:  2001-10-08     Completed Date:  2001-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1029-32     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Affiliation:
Shanghai Institute of Planned Parenthood Research, Shanghai, P. R. China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animal Population Groups
Animals
Embryo Implantation / drug effects*
Endometrium / drug effects,  physiology*
Estradiol / pharmacology
Female
Gonadal Steroid Hormones / pharmacology*
Growth Inhibitors / metabolism,  pharmacology*
Interleukin-6*
Leukemia Inhibitory Factor
Lymphokines / metabolism,  pharmacology*
Mifepristone / pharmacology
Pregnancy
Pregnancy, Animal / drug effects,  physiology*
Progesterone / pharmacology
Rabbits
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Growth Inhibitors; 0/Interleukin-6; 0/Leukemia Inhibitory Factor; 0/Lymphokines; 50-28-2/Estradiol; 57-83-0/Progesterone; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of human oviductal epithelial cell cultural medium on cryopreserved human sperm survival.
Next Document:  Upregulation of cystic fibrosis transmembrane conductance regulator expression by oestrogen and Bak ...