Document Detail


Effects of leucine or whey protein addition to an oral glucose solution on serum insulin, plasma glucose and plasma amino acid responses in horses at rest and following exercise.
MedLine Citation:
PMID:  21059029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
REASONS FOR PERFORMING STUDY: Providing protein or amino acid mixtures in combination with glucose to post exercise in man has resulted in increases in the post feeding insulin response and in muscle glycogen and protein synthesis rates. However, whether protein and/or amino acids can modify the post exercise insulin responses in horses remains to be fully elucidated.
OBJECTIVES: To determine whether whey protein or leucine addition to a glucose solution affects the post gavage plasma insulin, glucose and amino acid responses in horses and whether these responses are different following a period of exercise vs. rest.
METHODS: Six mature, conditioned Thoroughbreds received a nasogastric gavage containing either 1 g/kg bwt glucose (G), G + 0.3 g/kg bwt whey protein (GW) or G + 0.3 g/kg bwt leucine (GL), following a period of either rest (R) or an exercise test on a high speed treadmill (EX). Each horse was studied under all 6 treatment conditions, separated by 10 day intervals. Blood samples were collected pre-exercise/rest, pregavage and at regular intervals up to 300 min post gavage. Plasma was analysed for glucose and amino acid concentrations and serum insulin concentrations were determined.
RESULTS: There was a significantly (P < 0.05) greater insulin response in GL-R and GL-EX when compared to the other treatments. When compared to rest, post exercise plasma glucose responses were lower in G and GW but unchanged following GL administration. Plasma alanine concentrations were elevated post exercise in all EX treatments. With the exception of markedly elevated plasma leucine concentrations after GL-R and GL-EX, the plasma concentrations of all indispensable amino acids decreased during the post gavage period.
CONCLUSIONS: Leucine but not whey protein augmented the serum insulin response to an oral glucose load. Leucine supplementation warrants further investigation as a means to increase the rate of post exercise muscle glycogen synthesis in horses.
Authors:
K L Urschel; R J Geor; H L Waterfall; A K Shoveller; L J McCutcheon
Related Documents :
10573229 - Exhaled nitric oxide among pulpmill workers reporting gassing incidents involving ozone...
4063219 - Changes in the sense of balance correlate with concentrations of m-xylene in venous blood.
24149699 - The effects of regular aerobic exercise on renal functions in streptozotocin induced di...
22379729 - Validation of the basic psychological needs in exercise scale in a portuguese sample.
11952999 - Impact of uva exposure on psychological parameters and circulating serotonin and melato...
4015999 - Byssinosis in hong kong.
16767609 - Effects of external light loading in power-type strength training on muscle power of th...
1390969 - Effect of active hand exercise and wax bath treatment in rheumatoid arthritis patients.
3534509 - A randomized exercise trial in older women: increased activity over two years and the f...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-08-17     Revised Date:  2012-06-13    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-54     Citation Subset:  IM    
Copyright Information:
© 2010 EVJ Ltd.
Affiliation:
Department of Animal and Food Sciences, University of Kentucky, Kentucky, USA. klur222@uky.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / blood,  metabolism
Animal Feed / analysis
Animal Nutritional Physiological Phenomena
Animals
Blood Glucose / drug effects*
Diet / veterinary
Dietary Supplements
Female
Glucose / administration & dosage*,  pharmacology
Horses / blood,  physiology*
Insulin / blood*
Leucine / pharmacology*
Male
Milk Proteins / pharmacology*
Muscle, Skeletal / chemistry,  metabolism
Physical Conditioning, Animal / physiology
Rest / physiology
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/Insulin; 0/Milk Proteins; 0/whey protein; 50-99-7/Glucose; 61-90-5/Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of crude protein intake from forage-only diets on muscle amino acids and glycogen levels in ...
Next Document:  Dietary energy source and physical conditioning affect insulin sensitivity and skeletal muscle gluco...