Document Detail


Effects of lesions of the caudal cerebellar vermis on cardiovascular regulation in awake cats.
MedLine Citation:
PMID:  12031536     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The vestibular system is known to participate in cardiovascular regulation during movement and postural alterations. The present study considered whether lesions of two regions of the posterior cerebellar vermis (the nodulus and uvula) that provide inputs to vestibular nucleus regions that affect control of blood pressure would alter cardiovascular responses during changes in posture. Blood pressure and heart rate were monitored in awake cats during nose-up tilts up to 60 degrees in amplitude before and following aspiration lesions of the nodulus or uvula; in most animals, cardiovascular responses were also recorded following the subsequent removal of vestibular inputs. Lesions of the nodulus or uvula did not affect baseline blood pressure or heart rate, although cardiovascular responses during nose-up tilts were altered. Increases in heart rate that typically occurred during 60 degrees nose-up tilt were attenuated in all three animals with lesions affecting both dorsal and ventral portions of the uvula; in contrast, the heart rate responses were augmented in the two animals with lesions mainly confined to the nodulus. Furthermore, following subsequent removal of vestibular inputs, uvulectomized animals, but not those with nodulus lesions, experienced more severe orthostatic hypotension than has previously been reported in cerebellum-intact animals with bilateral labyrinthectomies. These data suggest that the cerebellar nodulus and uvula modulate vestibulo-cardiovascular responses, although the two regions play different roles in cardiovascular regulation.
Authors:
M J Holmes; L A Cotter; H E Arendt; S P Cass; B J Yates
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  938     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-28     Completed Date:  2002-08-08     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  62-72     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Cats
Cerebellum / physiology*,  physiopathology,  surgery
Electrocardiography
Electromyography
Female
Heart Rate*
Hypotension, Orthostatic / physiopathology*
Time Factors
Uvula / surgery
Vestibular Nuclei / physiology
Grant Support
ID/Acronym/Agency:
DC00693/DC/NIDCD NIH HHS; DC03417/DC/NIDCD NIH HHS; DC03732/DC/NIDCD NIH HHS; DC05205/DC/NIDCD NIH HHS; EY08098/EY/NEI NIH HHS; R01 DC000693/DC/NIDCD NIH HHS; R01 DC000693-11/DC/NIDCD NIH HHS
Investigator
Investigator/Affiliation:
M J Holmes / U Pittsburgh, PA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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