Document Detail

Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight.
MedLine Citation:
PMID:  17517446     Owner:  NLM     Status:  MEDLINE    
In this report, we examine the effects of leptin on the intake of specific macro- and micronutrients in a female patient with leptin gene deficiency. The patient was studied off and on leptin at stable body weight, within the normal to mildly overweight range. The data were obtained by detailed dietary assessments, measuring dietary intakes by weighed food and fluid consumption records, and analyzed using nutrition analysis software. Overall, significant differences were found in the off versus on leptin treatment periods in the following categories: (i) macronutrients: kilocalories, protein, carbohydrates, monounsaturated fats, MFA 18:1 oleic and total fiber; (ii) vitamins: vitamin C, pyridoxine and pantothenic acid; (iii) minerals: potassium, magnesium, copper and chromium; and amino acids: threonine, lysine and histidine. The nutritional data from this study indicates a direct link between the effects of leptin and ingestion of several specific micronutrients. The mechanisms underlying these effects warrant further investigation and study.
Julio Licinio; Michael Milane; Sarika Thakur; Fiona Whelan; Bulent O Yildiz; Tuncay Delibasi; Patricia B de Miranda; Metin Ozata; Erol Bolu; Alex Depaoli; Ma-Li Wong
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-06
Journal Detail:
Title:  Appetite     Volume:  49     ISSN:  0195-6663     ISO Abbreviation:  Appetite     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-09     Completed Date:  2008-03-11     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  594-9     Citation Subset:  IM    
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MeSH Terms
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Dietary Fiber / administration & dosage
Dietary Proteins / administration & dosage
Energy Intake / drug effects*,  physiology
Leptin / deficiency*,  genetics,  pharmacology*
Micronutrients / administration & dosage
Satiation / drug effects*,  physiology
Grant Support
DK063240/DK/NIDDK NIH HHS; DK58851/DK/NIDDK NIH HHS; HG002500/HG/NHGRI NIH HHS; HL04526/HL/NHLBI NIH HHS; K24 RR016996/RR/NCRR NIH HHS; K24 RR016996-01/RR/NCRR NIH HHS; K24 RR016996-02/RR/NCRR NIH HHS; K24 RR016996-03/RR/NCRR NIH HHS; K24 RR016996-04/RR/NCRR NIH HHS; K24 RR016996-05/RR/NCRR NIH HHS; K24 RR016996-06/RR/NCRR NIH HHS; M01 RR000865/RR/NCRR NIH HHS; M01 RR000865-310706/RR/NCRR NIH HHS; M01 RR000865-310723/RR/NCRR NIH HHS; M01 RR000865-320706/RR/NCRR NIH HHS; M01 RR000865-320723/RR/NCRR NIH HHS; M01 RR000865-338725/RR/NCRR NIH HHS; M01 RR000865-338779/RR/NCRR NIH HHS; MH062777/MH/NIMH NIH HHS; R01 DK058851/DK/NIDDK NIH HHS; R01 DK058851-01/DK/NIDDK NIH HHS; R01 DK058851-02/DK/NIDDK NIH HHS; R01 DK058851-03/DK/NIDDK NIH HHS; R01 DK058851-04/DK/NIDDK NIH HHS; R01 DK058851-05/DK/NIDDK NIH HHS; RR000865/RR/NCRR NIH HHS; RR017365/RR/NCRR NIH HHS; RR16996/RR/NCRR NIH HHS
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Leptin; 0/Micronutrients

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